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解毒活血中药对急性冠脉综合征患者PCI术后CD40-L及tPA的影响 被引量：4

The Influence of Jiedu Huoxue Decoction on CD40-L and tPA in Acute Coronary Syndrome after Percutaneous Coronary Intervention
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摘要 目的检测解毒活血中药对急性冠脉综合征(ACS)患者冠脉介入术(PCI)术后白细胞分化抗原40及其配体(CD40-L)及组织型纤溶酶原激活剂(tPA)的影响,探讨解毒活血中药治疗急性冠脉综合征不稳定斑块的机制。方法采用经皮Seldinger穿刺法或经桡动脉穿刺法选择性冠脉造影术。检测PCI术前及PCI术后用药30d后采用酶联免疫吸附法(ELISA)分别测定CD40-L、tPA水平。结果治疗组治疗后CD40-L及tPA水平下降更明显(P<0.05)。结论解毒活血中药能降低ACS患者PCI术后CD40-L及tPA水平,抑制PCI术后炎症。 Objective To explore the effects of Jiedu Huoxue deeoction（JHD） on CD40 - L and tissue - type plasminogen activator （tPA） in acute coronary syndrome（ACS） after percutaneous coronary intervention（PCI）. Methods Fifty patients with ACS after PCI were randomly divided into two groups： Treatment group treated by JHD and routine treatment, control group treated by routine treatment for 30 days. The levels of CD40I. and tPA were examined by ELISA. Results After treatment, the levels of CD40L and tPA in treatment group were lower than that in control group（P〈0.05）. Conclusion JHD could downregulate the levels of CD40L and tPA in patients with ACS after PCI.
作者 卢正华 孔刚 宫丽鸿
机构地区 辽宁中医药大学附属医院 辽宁省沈阳市妇婴医院
出处 《中西医结合心脑血管病杂志》 2012年第7期781-783,共3页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金 辽宁省科技计划重大基金项目(No.2008225010-22) 辽宁省沈阳市科委科研基金项目(No.1071215)
关键词 急性冠脉综合征 白细胞分化抗原40及其配体 组织型纤溶酶原激活剂 解毒活血汤 acute coronary syndromes CD40 - L tissue - type plasminogen activator Jiedu H uoxue decoction
分类号 R259 [医药卫生—中西医结合]
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参考文献9

  • 1Hochman JS, Lamas GA, Buller CE, et al. Coronary intervention for persistent occlusion after myocardial infarction: The occluded artery trial (OAT)[J]. N Engl J Med, 2006,355(23): 1056 - 1065.
  • 2Liao DF, Jin ZG, Baas AS, et al. Purification and identification of secreted oxidative stress induced factors from vascular smooth muscle cells[J]. J Biol Chem,2000,275 189 - 196.
  • 3宋月霞,王建华,刘兰燕,李路明,邢恒国.背向散射积分技术评价冠心病患者颈动脉粥样斑块的研究[J].中国医学影像技术,2003,19(10):1303-1305. 被引量：9
  • 4毛以林,谭光波,袁肇凯,黄献平,彭素娟.高敏C反应蛋白和可溶性细胞间黏附分子-1与冠心病血瘀证的相关性研究[J].新中医,2007,39(3):25-26. 被引量：11
  • 5柏正平,谭光波,卜献春,孙春林.冠心病中医辨证分型与细胞黏附分子的关系[J].中西医结合心脑血管病杂志,2006,4(2):108-109. 被引量：12
  • 6Mach F,Schonbeck U,Bonnefoy JY,etal. Activation of monocyte/macrophage functions related to acute atheroma complication by ligation of CD40 Induction of collagenase, stromelysin, and tissue factor[J]. Circulation, 1997,96 396 - 399.
  • 7Alderson MR, Armitage RJ, Tough TW, et al. CD40 expression by human monocytes: Regulation by cytokines and activation of mon- ocy tes by the ligand for CD40[J]. J Exp Med, 1993,178 669 - 674.
  • 8Hollenbaugh D, MischelPetty N, Edwards CP, et al. Expression of functional CD40 by vascular endothe lialcells[J]. J Exp Med, 1995, 182,33 -40.
  • 9Solomao V, Stomspm V, Kark JD, et al. Asociation of fibrinolytic parameters with early atheroselerosis:The ARIC Study[J]. Circu- lation, 1995,91 : 284 - 290.

二级参考文献19

  • 1王红艺,李海萍,乔远静,刘志福.冠心病患者高敏C反应蛋白变化的临床意义[J].山东医药,2006,46(13):54-54. 被引量：2
  • 2国家技术监督局.中华人民共和国国家标准中医临床诊疗术语[M].北京:中国标准出版社,1997.17-19.
  • 3Ross R. Atheroscleros inflammatory disease [J]. Nengl Med,1999,340(2) : 115 - 126.
  • 4Omalley T, Ludlam CA, Riemermsa RA, et al. Early increaseiv levels of soluble inter cellularmolecule-1 ( sICAM - 1 ). Potential risk factor for the coronary syndromes[J]. Eur Heart J,2001,22:1226 - 1234.
  • 5Rasheed Q, Nair R, Sheehan H, et al. Correlation of intracoronary ultrasound plaque characteristics in atherosclerotic coronary artery disease patients with clinical variables[J]. Am J Cardiol,1994, 73(11):753-758.
  • 6Zahi Khoury, Rama Schwartz, Shmuel Gottlieb, et al. Relation of Coronary Artery Disease to Atherosclerotic Disease in the Aorta,Carotid, and femoral Arteries Evaluated by Ultrasound[J]. Am J Cardiol, 1997,80(11) :1429-1433
  • 7Hodgson J M, Reddy KG, Suneja R, et al. Intracoronary ultrasound imaging correlation of plaque morphology with angiographic clinical syndrome and procedural results in patients undergoing coronary angioplasty[J]. J Am Coll Cardiol, 1993,21 ( 1 ) :35-44.
  • 8Bocksch W, Schartl M, Beckmann S, et al. Intravascular ultrasound imaging in patients with acute myocardial infarction[J]. Eur Heart J, 1995,16(Suppl I) :46-52.
  • 9Holland MR, Hall CS, Lewis SH, et al. Comparison of integrated backscatter values obtained with acoustic densitometry with values derived from spectral analysis of digited signals from a clinical imaging system.[J].J Am Soc Echocardiogr, 1997,10(5 ):511-517.
  • 10国家中医药管理局.中华人民共和国中医药行业标准[M].南京:南京大学出版社,1994.132.

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中西医结合心脑血管病杂志
2012年 第7期

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