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心肌缝隙连接蛋白43与心血管疾病的关系 被引量：4

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摘要 心脏缝隙连接(gap junction,GJ)是细胞间进行电化学偶联及信息交换的重要途径,是介导心脏维持正常的协调性和同步性功能的重要桥梁及特殊通道。GJ主要由连接蛋白组成,而在心肌细胞水平上主要包括连接蛋白(connexin,Cx)43、Cx40和Cx45,但各自在心脏部位的表达分布和功能上却有所不同。现已有研究报道分析在许多心血管疾病中,GJ在结构和功能上的改变或异常与主要心血管事件的发生有直接关联。Cx含量及分布的减少、GJ调控因素的影响及GJ的侧-侧连接导致传导异向性变化等,均可能使心脏整体功能活动不同程度地下降或受到抑制,从而引起心脏疾病的发生和发展。
作者 黄强辉 胡建新
机构地区 南昌大学第二附属医院心内科
出处 《岭南心血管病杂志》 2012年第1期81-84,共4页 South China Journal of Cardiovascular Diseases
关键词 肌细胞 心脏 连接蛋白类 心血管疾病 心律失常
分类号 R541 [医药卫生—心血管疾病]
  • 相关文献

参考文献25

  • 1YEAGER M. Structure of cardiac gap junction intercellular channels[J]. J Struct Biol, 1998, 121(2) : 231-145.
  • 2EVANS W H, MARTIN P E. Gap junctions: structure and function(Review) [J]. Mol nembr Siol, 2002, 19(2) : 121- 136.
  • 3GROS D B, JONGSMA H J. Connexins in mammalian heart function[J]. Bioessays, 1996, 18(9): 719-730.
  • 4MORENO A P, ROOK M B, FISHMAN G L, et al. Gap junction channels: distinc voltage-sensitive and insensitive conductance states[J]. Biophys J, 1994, 67( 1 ) : 113-119.
  • 5REAUME A G, DE SOUSA P A, KULKAMI S, et al. Cardiac malformation in neonatal mice lacking connexin43 [ J ]. Science, 1995, 267(5205) : 1831-1834.
  • 6DUPONT E, MATSUSHITA T, KABA R A, et al. Altered connexin expression in human congeative heart failure [J]. J Mol Cell Cardiol, 2001, 33(2): 359-371.
  • 7PETERS N S, GREEN C R, POOLE-WILSON P A,et al. Reduced content of connexin43 gap junctions in ventricular myocardium from hypertrophied and ischemic human hearts [J]. Circulation, 1993, 88(3): 864-875.
  • 8AKAR F G, SPRAGG D D, TUNIN R S, et al. Mechanisms underlying conduction slowing and arrhythmogenesis in nonischemic dilated cardiomyopathy [J]. Circ Res, 2004, 95 (7) : 717-725.
  • 9KAPRIELIAN R R, GUNNING M, DUPONT E, et al. Downregulation of inmunodetectable eonnexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle [ J ]. Circulation, 1998,97 (7) : 651 - 660.
  • 10BEARDSLEE M A, LERNER D L, TADROS P N, et al. Dephosphorylation and intracellular redistribution of ventricular connexin43 during electrical uncoupling induced by ischemia [J]. Cite Res, 2000, 87(8): 656-662.

二级参考文献18

  • 1Evans FG, Rogers JM,Smith WM, et al. Automatic detection of conduction block based on time - frequency analysis d unipolar electrograms[J]. IEEE. Trans Biomed Fag, 1999, 46(9): 1090 -1097.
  • 2Rudy Y, Shaw RM. Cardiac excitation: an interactive process of ion channels and gap junctions[J]. Adv Exp Med Biol,1997,430(3) :269 - 279.
  • 3Thomas SA, Schuessler RB, Berul CI, et al. Disparate effects of deficient expression of connexin 43 on atrial and ventricular conduction[J]. Circulation, 1998,97(7):685-691.
  • 4Van Kempen MJ, Fromaget C, Gros D, et al. Spatial distribution of connexin43, the major cardiac gap junction protein,in the developing and adult rat heart[J]. Circ Res, 1991, 68(6) : 1638 - 1651.
  • 5Gros DB, Jongsma HJ. Connexins in mananalian heart[J] .Bioessays, 1996, 18(9) :719- 730.
  • 6Jongsma HJ, Wilders R. Gap junctions in cardiovascular disease[j].Circ Res, 2OOO, 86(12):1193- 1197.
  • 7Peters NS. New insights into myocardial arrhyflrmgenesis: distribuaion of gap junctional coupling in normal, ischemic and hypertrophied hearts[J]. Clin Sci Colch, 1996, 90(6):447-452.
  • 8Shl G, Willecke K. Gap junctions and the connexin protein family. Cardiovasc Res. 2004; 62(2):228-232.
  • 9Gutstein DE, Morley GE, Fishman GI. Conditional gene targeting of connexin43: exploring the consequences of gap junction remodeling in the heart. Cell Commun Adhes. 2001;8(4-6):345-348.
  • 10Pellizz o n OA, Beloscar JS, Mariani E. Adrenergic nervous system influences on the induction of ventricular tachycardia. Ann Noninvasive Electrocardiol. 2002;7(4):281-288:

共引文献23

同被引文献62

  • 1程宏勇,张钲,白锋,杨彩兰,朱惠.室速发作与T波峰-末间期的关系[J].临床心电学杂志,2006,15(1):16-18. 被引量：26
  • 2王荣,张存泰,阮燕菲,刘念,王琳.大鼠心肌急性缺氧时缝隙连接蛋白43磷酸化水平的改变及心律失常肽10对其影响[J].临床心血管病杂志,2007,23(5):375-378. 被引量：13
  • 3王荣,张存泰,刘念,阮燕菲,王琳.抗心律失常肽对乳鼠心肌细胞急性缺氧时细胞间传导的影响[J].华中科技大学学报（医学版）,2007,36(5):574-577. 被引量：3
  • 4Murdock DK, Loeb JM, Euler DE,et al. Electrophysiology of cor- onary reperfusi0n. A inechanism for reperfusion arrhythmias [ J ]. Circulation, 1980,61 ( 1 ) : 175 - 182.
  • 5Manning AS, Hearse DJ. Reperfusion - induced arrhythmias : mechanisms and prevention [ J ]. J Mol Cell Cardiol, 1984,16 (6) :497 -518.
  • 6Prinzmetal M, Kennamer R, Merliss R, et al. Angina pectoris, t. A variant form of angina pectoris ; preliminary report [ J ]. Am J Med, 1959,27:375 - 388.
  • 7Yoshida Y, Hirai M, Yamada T, et al. Antiarrhythmic efficacy of dipyridamole in treatment of reperfusion arrhythmias : evidence for cAMP - mediated triggered activity as a mechanism responsible for reperfusion arrhythmias [ J ]. Circulation, 2000,101 ( 6 ) : 624 -630.
  • 8Sheehan FH, Epstein SE. Determinants of arrhythmic death due to coronary spasm : effect of preexisting coronary artery stenosis on the incidence of reperfusion arrhythmia [ J ]. Circulation, 1982,65 (2) :259 -264.
  • 9Grech ED, Ramsdale DR. Termination of reperfusion arrhythmia by coronary artery occlusion [J]. Br Heart J, 1994,72( 1 ) :94 - 95.
  • 10Yao YT, Li LH, Chen L, et al. Sevoflurane postconditioning pro- tects isolated rat hearts against ischemia - reperfusion injury: the role of radical oxygen species, extracellular signal - related kinases 1/2 and mitochondrial permeability transition pore [ J]. Mol Biol Rep, 2010,37(5 ) :2439 -2446.

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二级引证文献14

岭南心血管病杂志
2012年 第1期

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