期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

异氟醚和卡托普利联合预处理对兔心肌缺血-再灌注细胞超微结构的影响 被引量：5

Effect of isoflurane combined with captopril preconditioning on myocardial ultrastructure after ischemia and reperfusion injury in rabbit
下载PDF
导出
摘要 目的观察异氟醚、卡托普利联合预处理对兔心肌缺血-再灌注心肌细胞超微结构的作用。方法新西兰大白兔48只,随机均分为六组:假手术组(S组)、单纯缺血-再灌注组(IR组)、缺血预处理组(IPC组)、异氟醚组(I组)、卡托普利组(C组)和异氟醚、卡托普利联合预处理组(IC组)。采用结扎冠状动脉左前降支法制备兔心肌缺血-再灌注模型。观察各组心肌细胞超微结构变化。结果 IPC组心肌细胞损伤轻于IR组,IC组损伤最轻。结论异氟醚、卡托普利联合预处理对缺血-再灌注兔心肌细胞超微结构有更好的保护作用。 Objective To investigate the cardioprotective effect of isoflurane combined with captopril preconditioning on myocardial ischemia reperfusion injury in rabbit. Methods Forty-eight healthy New Zealand white rabbits were randomly assigned to sham-operated group （group S）, ischemia/reperfusion group（group IR）, ischemic preconditioning group（group IPC）, isoflurane group （group I）, captopril group（group C）, and isoflurane together with captoril group（group IC）. The model of the myocardial ischemia reperfusion was prepareed by ligating the left anterior descending coronary artery. The myocardial ultrastructures were investigated by electron microscope. Results Compared with group IR, the myocardial injury was relieved in group IPC, and it is most significant in group IC. Conclusion The combination of isoflurane and captopril preconditioning has a myocardial protective effect against ischemia reperfusion injury in rabbits.
作者 田毅 柳培雨 田国刚 徐军美
机构地区 中南大学湘雅医学院附属海口医院麻醉科 武警海南总队医院麻醉科 中南大学湘雅二医院麻醉科
出处 《临床麻醉学杂志》 CAS CSCD 北大核心 2012年第6期602-604,共3页 Journal of Clinical Anesthesiology
基金 海南省2008年度自然科学基金资助项目(808242)
关键词 异氟醚 卡托普利 预处理 心肌超微结构 缺血-再灌注损伤 Isoflurane Captopril Combined drug preconditioning Myocardium ultrastructure Ischemia reperfusion
分类号 R965 [医药卫生—药理学]
  • 相关文献

参考文献8

  • 1Aronow WS. Epidemiology, Pathophysiology, prognosis, and treatment of systolic and diastolic heart failure. Cardiol Rev, 2006,14(3) : 108-124.
  • 2Ebrahim Z, Yellon DM, Baxter GF. Ischemic preconditioning is lost in aging hypertensive rat heart: independent effects of aging and longstanding hypertension. Exp Gerontol, 2007, 42 (8): 807-814.
  • 3A1-Maghrebi M, Benter IF, Diz DI. Endogenous angiotensin(1-7) reduces cardiac ischemia-induced dysfunction in diabetic hypertensive rats. Pharmacol Res,2009,59(4): 263-268.
  • 4Zhu J, Rebecchi MJ, Tan M, et al. Age-associated differences in activation of Akt/GSK-3beta signaling pathways and inhibi- tion of mitoehondrial permeability transition pore opening in the rat heart. J Gerontol A Biol Sci Med Sei, 2010, 65(6) :611- 619.
  • 5Turner LA, Fujimoto K, Suzuki A, et al. The interaction of isoflurane and protein kinase C-activators on sareolemmal KATP channels. Anesth Analg, 2005, 100(6): 1680-1686.
  • 6Pravdic D, Mio Y, Sedlic F, et al. Isoflurane protects cardio- myoeytes and mitochondria by immediate and cytosol-inde- pendent action at reperfusion. Br J Pharmacol, 2010,160(2) 220-232.
  • 7李进,袁世荧,丰新民.诱导型一氧化氮合酶在异氟醚延迟相预处理心肌保护中的作用[J].临床麻醉学杂志,2008,24(8):676-678. 被引量：3
  • 8Luca MC, Liuni A, DiFabio J, et al. The acute administration of either amiloride or captopril does not prevent endothelial dysfunction induced by ischemia and reper{usion in the human forearm vasculature. Can J Physiol Pharmacol, 2010, 88(10) : 996-1001.

二级参考文献6

  • 1Tanaka K, Lynda LM,Krolikowski JG, et al. Isoflurane produces delayed preconditioning against myocardial ischemia and reperfusion injury: role of cyclooxygenase 2. Anesthesiology, 2004, 100:525-531.
  • 2Bolli R. The late phase of preconditioning. Circ Res, 2000,87: 972-983.
  • 3Xuan YT, Tang XL, Qiu Y,et al. Biphasic response of cardiac NO synthase isoforms to ischemic preconditioning in conscious rabbits. Am J Physiol Heart Circ Physiol, 2000,279:H2360-H2371.
  • 4Wang Y, Guo Y, Zhang SX, et al. Ischemic preconditioning upregulates inducible nitric oxide synthase in cardiac myocyle. J Mol Cell Cardiol,2002,31: 5-15.
  • 5Guo Y, Jones WK, Xuan YT, et al. The late phase of ischemic preconditioning is abrogated by largeted disruption of the inductble NO synthasc gene. Proc Natl Acad Sci USA, 1999, 96:1157-11512.
  • 6Takano H, Tang XL, Qiu Y,et al. Nitric oxide donors induce late preconditioning against myocardial stunning and infarction in conscious rabbits via an antioxidant sensitive mechanism. Circ Res, 1998,83:73-81.

共引文献2

同被引文献40

  • 1张红,张蓓,汤伯瑜,陈莹莹,朱立,沈岳良.一氧化氮和线粒体ATP敏感性钾通道介导血管紧张素转换酶抑制剂加强阈下预处理的作用[J].生理学报,2005,57(4):453-460. 被引量：9
  • 2周齐娜,李源,陈富华.缺血预处理对兔心肌细胞凋亡的影响[J].武警医学,2010,21(2):127-130. 被引量：1
  • 3Aronow W S. Epidemiology, Pathophysiology, prognosis, and treatment of systolic and diastolic heart failure[J]. Cardiol Rev, 2006,14 (3) : 108-124.
  • 4Kodaka M,Johansen J W,Sebel P S. The influence of gender on loss of consciousness with sevoflurane or propofol[J]. Anesth Analg,2005, 101 (2) :377-381.
  • 5Zhu J,Rebecchi M J,Tan M,et al. Age-associated differences in ac- tivation of Akt/GSK-3beta signaling pathways and inhibition of mito- chondrial permeability transition pore opening in the rat heart[J]. J Gerontol A Biol Sci Med Sci,2010,65(6):611-619.
  • 6Krolikowski J G,Bienengraeber M,Weihrauch D,et al. Inhibition of mitochondrial permeability transition enhances isoflurane-induced cardioprotection during early reperfusion: the role of mitochondrial KATP channels[J]. Anesth Analg, 2005,101 : 1590-1596.
  • 7Pravdic D ,Mio Y, Sedlic F,et al. Isoflurane protects cardiomyocytes and mitochondria by immediate and cytosol-independent action at reperfusion[J]. Br J Pharmaco1,2010,160(2) :220-232.
  • 8Luca MC, Liuni A, DiFabio J, et al. The acute administration of either amiloride or captopril does not prevent endothelial dysfunction induced by ischemia and reperfusion in the human forearm vasculature[ J]. Can J Physiol Pharmacol,2010,88(10) :996 - 1001.
  • 9Penna C,Tullio F, Moro F, et al. Effects of a protocol of ischemic post- conditioning and/or captopril in hearts of normotensive and hypertensive rats [ J ]. Basic Res Cardio1,2010,105 (2) : 181 - 192.
  • 10Chiari PC, Pagel PS,Tanaka K,et al. Intravenous emulsified halogenated anesthetics produce acute and delayed preconditioning against myocardi- al infarction in rabbits [ J 1. Anesthesiology, 2004, 101 ( 5 ) : 1160 - 1166.

引证文献5

二级引证文献15

临床麻醉学杂志
2012年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部