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细胞周期调控蛋白在细胞周期调控中的作用及与心脏发育的关系 被引量：1

Functions of Cell Cycle Regulation Protein in Cell Cycle Regulation and Relationship with Heart Development
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摘要 细胞周期调控是一个很复杂的过程,其通过促进有丝分裂的调节因子和抑制有丝分裂的调节因子的精细平衡来完成。其中促进有丝分裂的调节因子包括细胞周期素、细胞周期蛋白依赖性激酶、真核生物起始因子3a等。现主要阐述细胞周期调控蛋白如细胞周期素、细胞周期分裂基因2、真核生物起始因子3a、细胞周期素依赖激酶抑制因子家族在细胞周期中的作用及在心脏发育中的作用。 Cell cycle regulation is a very complicated process, completed of fine balance by promoting the mitotic adjustment factor and inhibit mitotic adjustment factor. Promoted mitotic adjustment factors which include cell cycle elements, cell cycle protein kinase dependence, eukaryotes starting factor 3a,etc. This review mainly expounds the functions of the cell cycle regulation protein such as cell cycle elements, CDC2, eukaryotes starting factor 3a, CIP/KIP family in the cell cycle regulation process and the role in heart development.
作者 康婷 杨作成
机构地区 中南大学湘雅三医院儿科
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2012年第13期1019-1022,共4页 Journal of Applied Clinical Pediatrics
关键词 细胞周期调控 真核生物起始因子3a 细胞周期分裂基因2 CYCLIN D1 CYCLIN B1 cell cycle regulation eukaryotes starting factor 3a CDC2 cyclin D1 cyclin B1
分类号 R725.4 [医药卫生—儿科]
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参考文献32

  • 1Choi HJ, Fukui M, Zhu BT. Role of cyclin B1/Cdc2 up - regulation in the development of mitotic prometaphase arrest in human breast cancer cells treated with nocodazole [ J ]. PLoS One,2011,6 ( 8 ) : e24312.
  • 2Fidalgo da Silva E, Ansari SB, Maimaiti J, et al. The tumor suppressor tuberin regulates mitotic onset through the cellular localization of cyclin B1 [J]. Cell C~cle.2011,10(18) :3129 -3139.
  • 3Sakai K, Barnitz RA, Chaigne - Delalande B, et al. Human immunodefi- ciency virus type 1 Vif causes dysfunction of Cdkl and CyclinB1 :Impli- cations for cell cycle arrest[J]. Virol J,2011,8(8) :219.
  • 4Browning KS, Gallie DR, Hershey JW,et al. Unified nomenclature for the subunits of eakaryotic initiation factor 3 [ J ]. Trends Biochem Sci, 2001, 26(5) :284.
  • 5Masutani M, Sonenberg N, Yokoyama S, et al. Reconstitution reveals the functional core of mammalian eIF3 [ J ]. EMBO J, 2007,26 ( 14 ) :3373 - 3383.
  • 6Kovarik P, Hasek J, ValOsek L, et al. RPG1 :An essential gene of saceha- romyees eerevisiae encoding a 110 - kDa protein required for passage through the G1 phase [ J ]. Curt Genet, 1998,33 ( 2 ) : 100 - 109.
  • 7Dong Z, Liu LH, Han B, et al. Role of eIF3 p170 in controlling synthesis of ribonucleotide reductase M2 and cell growth[ J]. Oncogene,2004,23 (21) :3790 -3801.
  • 8Dong Z,Liu Z,Cui P,et al. Role of elF3a in regulating cell eyete pro- gression[ J ] . Exp Cell Res ,2009 ,315 ( l l ) :1889 -1894.
  • 9Dong Z, Zhang JT. EIF3 p170, a mediator of mimosine effect on protein synthesis and cell cycle progression [ J ]. Mol Biol Cell, 2003,14 ( 9 ) : 3942 - 3951.
  • 10Xu TR, Lu RF, Romano D,et al. Eukaryotic translation initiation factor 3, subunit a, regulates the extracellular signal - regulated kinase pathway[J]. Mol Cell Biol,2012,32( 1 ) :88 -95.

二级参考文献12

  • 1Golsteyn RM, Lane HA, Mundt KE, et al. The family of pololike kinases. Prog Cell Cycle Res, 1996, 2:107-14.
  • 2Dai W, Cogswell JP. Polo-like kinases and the microtubule organization center: Targets for cancer therapies. Prog Cell Cycle Res, 2003, 5:327-34.
  • 3Abrieu A, Brassac T, Galas S, et al. The polo-like kinase Plxl is a component of the MPF amplification loop at the G2/M- phase transition of the cell cycle in Xenopus eggs. J Cell Sci, 1998, 111(pt12):1751-7.
  • 4Kumagai A, Dunphy WG. Purification and molecular cloning of Plxl, a Cdc25-regulatory kinase from Xenopus egg extracts. Science, 1996, 273(5280): 1377-80.
  • 5Mueller PR, Coleman TR, Kumagai A, et al. Mytl: A membrane - associated inhibitory kinase that phosphorylates Cdc2 on both Threonine-14 and Tyrosine-15. Science, 1995b, 270(5233):86-90.
  • 6Qian YW, Erikson E, Maller JL. Purification and cloning of a protein kinase that phosphorylates and activates the pololike kinase Plxl. Science, 1998, 282(5394):1701-4.
  • 7Roshak AK, Capper EA, Imburgia C, et al. The human polo-like kinase, Plk, regulates cdc2/cyclin B through phosphorylation and activation of the CDC25C phosphatase. Cell Signal, 2000, 12(6):405-11.
  • 8Nigg EA. Polo-like kinases: Positive regulators of cell division from start to finish. Curr Opin Cell Biol, 1998, 10(6):776-83.
  • 9Fan HY, Tong C, Teng CB, et al. Characterization of polo-like kinase-1 in rat oocytes and early embryos implies its functional roles in the regulation of meiotic maturation, fertilization, and cleavage. Mol Reprod Dev, 2003, 65(3):318-29.
  • 10Stevenson CS, Capper EA, Roshak AK, et al. The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore. J Pharmacol Exp Ther, 2002a, 303(2): 858-66.

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实用儿科临床杂志
2012年 第13期

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