摘要
Background Fish oil, rich in long-chain n-3 PUFAs, EPA and DHA, are known to reduce various risk factors for CAD1-3. However, conclusive regarding the benefits of n-3 PUFAs on arterial stiffness, a risk factor for CAD, has not yet been established. Methods In the placebo-controlled, single-blind, prospective study, 60 subjects were randomly allocated to consume daily nutritional supplement of 3 gram capsules containing either placebo （soybean oil） or fish oil, EPA （540 mg） ＋ DHA （360 mg） for 12 weeks. Anthropometry, pulse wave velocity （PWV） and polyunsaturated fatty acid were measured and compared before and after study therapy. Results After study therapy, PWV reduced significantly in the fish oil group compared with the placebo group （-8 ± 18 cm/s vs 39 ± 19 cm/s, P 〈 0.05）. Conclusions Fish oil shows beneficial effect on improving arterial stiffness in patients with coronary disease.
Background Fish oil, rich in long-chain n-3 PUFAs, EPA and DHA, are known to reduce various risk factors for CAD1-3. However, conclusive regarding the benefits of n-3 PUFAs on arterial stiffness, a risk factor for CAD, has not yet been established. Methods In the placebo-controlled, single-blind, prospective study, 60 subjects were randomly allocated to consume daily nutritional supplement of 3 gram capsules containing either placebo （soybean oil） or fish oil, EPA （540 mg） ＋ DHA （360 mg） for 12 weeks. Anthropometry, pulse wave velocity （PWV） and polyunsaturated fatty acid were measured and compared before and after study therapy. Results After study therapy, PWV reduced significantly in the fish oil group compared with the placebo group （-8 ± 18 cm/s vs 39 ± 19 cm/s, P 〈 0.05）. Conclusions Fish oil shows beneficial effect on improving arterial stiffness in patients with coronary disease.
