肺硬化性血管瘤32例临床病理分析

Pulmonary Sclerosing Hemangioma:A Clinicopathologic Analysis of 32 Cases

目的:探讨肺硬化性血管瘤(PSH)的临床病理特征。方法:收集四家医院32例PSH,常规进行HE染色、免疫组织化学染色,光镜观察。结果:本组男3例,女29例,年龄31岁～62岁,平均51岁。左肺13例,右肺19例。镜下肿瘤由圆形间质细胞和立方形表面细胞构成,组织构像为实性区、乳头状区、血管瘤样区,硬化区,瘤细胞呈圆形、立方形,胞浆淡染或嗜酸性,核圆形,染色质匀细,很少核分裂。免疫组化示:2种细胞均表达TTF-1、EMA,立方形细胞表达PCK,间质细胞表达Vimentin,部分表达Syn、CgA、NSE。Ki-67<1%。患者术后随访未见复发及转移。结论:PSH是源于上皮的肿瘤,好发于中老年女性,预后良好。

Objective： To investigate the clinicopathological characteristics of pulmonary sclerosing hemangioma （PSH）. Methods： Thirty-two cases of PSH were studied by HE staining, immunohistochemical staining, light microscopy and clinical data. Results ： Of the 32 cases of PSH, 3 cases were males and 29 cases were females. The average age was 51 years old （ ranged from 31 to 62 years）. 13 cases were located in the left lung and 19 cases in the right lung. Pathological morphologic findings were solid, papillary, hemangiomatous, sclerotic pattern. Major structures of tumor cells were round and cuboidal. Cytoplasma was pale or red . Immuno- histochemistry results showed that both round and cuboidal cells expressed TTF- 1, EMA, cuhoidal ceils also expressed PCK, round ceils expressed Vimentin, Syn, CgA, NSE. Ki-67 〈 1%. Follow-up information was available in all cases, no recurrences and metastasis was found. Conclusion： PSH is a rare and epithelial lung tumor. It usually occurs in middle-aged women and have a good prognosis.