AST、CK、CK-MB、α-HBDH、LDH检测对高血压诊断的敏感性分析

目的调查心肌酶谱AST、CK、CK-MB、α-HBDH、LDH在高血压不同分级患者中的水平,探讨其在高血压及心肌损伤中的意义。方法选择2010年7月～2011年12月在本院门诊就诊及住院的高血压患者和血压正常者共698例为研究对象,测量血压后进行分组,共分为4组,分别为正常组、1级高血压组、2级高血压组和3级高血压组。用免疫抑制法测定CK-MB,苹果酸脱氢酶法测定AST,速率法测定CK、α-HBDH和LDH。结果高血压组SBP、DBP均较对照组增高(P<0.05),HR组间差异无统计学意义(P>0.05)。血清AST、CK、CK-MB、α-HBDH、LDH在正常组、1级高血压组、2级高血压组和3级高血压组中逐渐增高,CK、CK-MB、α-HBDH、LDH在正常组和高血压组之间差异均有统计学意义(P<0.05),AST在任何两组之间差异无统计学意义(P>0.05)。结论随着高血压的危险分级上升,心肌酶谱AST、LDH、CK、CK-MB、α-HBDH水平亦逐渐上升,心肌酶谱AST、LDH、CK、CK-MB、α-HBDH水平可以作为高血压诊断性评估的补充手段。

Objective To investigate the meaning of the myocardial enzymes levels in hypertensive patients with different levels for diagnoses of hypertension and myocardial injury. Methods Blood pressure is measured and the 698 cases during July 2010 to December 2011 are divided into four groups, namely the control group, hypertension level 1, 2 and 3 group. CK-MB is detected by immunity restrain assay, AST is detected by malate dehydrogenase assay, CK, α-HBDH and LDH are detected by continuous monitoring assay. Results SBP and DBP are higher in hypertension group than in the control group （P 〈0.05）, while HR is no significant difference between the groups （P〉 0.05）. Serums AST, CK, CK-MB, α-HBDH, LDH gradually increase in the control group, hypertension level 1, 2 and 3 group. CK, CK-MB, α-HBDH, LDH in the nor/hal group and hypertension groups have significantly differences （P 〈0. 05）.However, AST has no significantly difference between the two groups （P 〉 0.05）. Conclusion With hypertension risk level the increased, myocardial enzymes AST, LDH, CK, CK-MB, α-HBDH levels are gradually increased, Myocardial enzymes AST, LDH, CK, CK-MB, ot-HBDH levels might be a supplement method of assessing hypertension.