高原缺氧环境对青年战士血小板活化的影响

Effects of Hypoxia Environment on Blood Platelet Activation Among Young Soldiers Entering Plateau.

[目的 ]探讨高原低氧环境对青年战士血小板活化状态的影响。 [方法 ]对从平原 (海拔 12 0 0 m)进驻海拔 35 0 0 m、 40 0 0 m、 45 0 0 m高原 7天、 6月、 12月的 6 0名官兵进行血小板表面α-颗粒膜蛋白 (α- GMP- 140 )含量 ,血浆血栓素 B2 (TXB2 )水平 ,血小板聚集率 (PAR)等测定 ,并与 30名平原健康青年战士作对照。 [结果 ]高原战士α- GMP- 140含量 ,血浆 TXB2 和 PAR比平原战士有不同程度升高 (P<0 .0 5 ,或 P<0 .0 1) ;进驻以后 7天 ,6个月 ,12个月逐渐降低 ,进驻 12个月时α- GMP- 140 ,TXB2 和 PAR等指标较平原战士的升高无显著性 (P>0 .0 5 )。 [结论 ]健康青年战士进驻高原早期血小板高度活化 ,以后逐渐降低。因此 ,预防进驻高原后心血管疾病关键在早期预防。

Objective]To explore the effects of hypoxia environment on blood platelet activation among young soldiers entering plateau.[Methods]The contents of α granule membrane protein(α GMP 140) on the surface of blood platelet,the levels of thromboxane B 2(TXB 2) in plasma and platelet aggregation rate (PAR) were determined at 7th day,6th month and 12th month,when the observed 60 young soldiers came from plain with an altitude of 1 200 meters entering plateau with altitudes of 3 500,4 000 and 4 500 meters,and were compared with those among 30 healthy young soldiers in plain selected as controls.[Results]The contents of α granule membrane protein (α GMP 140),the levels of TXB 2 in plasma and PAR among soldiers entering plateau were significantly higher than those in plain with different degrees ( P<0 05 or P<0.01 ),and increased with the increase of altitudes,and decreased with the resident durations of 7days,6 months and 12 months.All of the observed 3 indexes of soldiers garrented in plateau afrer 12 month showed no significantly higher than those in plain( P>0 05 ).[Conclusion]The blood platelet activaiton increased among healthy young soldiers in the early stage of entering plateau,and then decreased.So early prevention was the key to prevent the occurrence of cardiovescular diseases among population entering plateau.