舒血宁治疗慢性精神分裂症经颅多普勒检测对照研究

A case-control study of the Measurement of Transcranial Doppler System （TCD） and SANS among 120 Chronic Schizophrenia in-hospital patients treated with Shu Xuening

目的 观察联合舒血宁治疗长期住院的慢性精神分裂症患者颅底动脉血流特点和对其阴性症状疗效.方法 应用经颅多普勒仪对长期慢性精神分裂症患者120例进行颅底各动脉平均血流速度（Vm）的测定,同时行阴性症状量表（SANS）评分,随机分为A、B两组,A组服用抗精神药物加舒血宁针剂12ml静脉滴注,B组仍用原药物治疗,8周后再行Vm测定,SANS量表评分作组内、组间对照.结果 长期住院的慢性精神分裂症的TCD异常,各动脉Vm减慢,8周后联合舒血宁治疗组脑血流改善明显,各动脉双侧大脑中动脉（MCA）、大脑前动脉（ACA）、大脑后动脉（PCA）及基底动脉（BA）血流与对照组有统计学差异（P＜0.05）;VA无差异（P ＞0.05）.并显示慢性精神患者血流减慢明显.Vm比合用前增加,较对照组增快,有显著差异（P＜0.05）;合用组阴性症量表减分显著（P＜0.05）.结论 合用舒血宁可以改善长期住院的慢性精神分裂症脑部血流,对阴性症状改善明显（P＜0.05）.

Objective To observe the character of the blood-flow of the basicranial arteries and the effect with shuxuening in negative schizophrenic patients. Methods 120 in-hospital schizophrenic patients were involved in the average blood flow in postcranial arteries （Vm） measurement as well as being assessed with SANS. The 120 patients were divided into group A and B, patients in group A were treated with antipsychotics and 12ml shuxuening dripping each day, while patients in group B took antipsychotics only. All the patients were measured by TCD and SANS and were compared between and within the groups. Results Patients with schizophrenia had abnormal appearance in TCD and the Vm scores decreased. After 8 weeks＇ therapy with shuxuening, group A patients got improvement in TCD results, the MCA, ACA, PCA and BA results in the arteries has statistical difference （p〈0.05）; while the VA results changed little. What is more, negative chronic schizophrenic patients have lower blood-flow in postcranial arteries. In group A, the Vm results were enhanced after the patients were treated with shuxuening and the blood flow was faster than that of Group B, which has a significant difference （p〈0.05）. The scores of group A in SANS declined statistically. Conclusion Treated with the combination of antipsychotics and shuxuening, the in-hospital chronic schizophrenic patients get more remission in negative symptoms and more blood flow in postcranial arteries..