脑膜瘤PR、ER、AR、p53、Ki-67、MYC、VEGF检测的临床意义

Expression of progesterone receptor, estrogen receptor, androgen receptor, Ki-67, p53, MYC, and vascular endothelial growth factor in meningioma tissue

目的 观察脑膜瘤组织中孕激素受体（PR）、雌激素受体（ER）、雄激素受体（AR）、p53、Ki-67、MYC、血管内皮细胞生长因子（VEGF）的表达,探讨它们与脑膜瘤恶性变及复发的关系.方法 收集64例脑膜瘤标本,应用组织芯片技术检测PR 、ER、AR、p53、Ki-67、MYC、VEGF在脑膜瘤细胞中的表达情况并进行分析.结果 PR、VEGE、p53、Ki-67、MYC在不同级别脑膜瘤组织中表达的差异有统计学意义（P＜0.05或0.01）.PR 、p53、Ki-67、MYC在复发与未复发脑膜瘤中表达的差异有统计学意义（P＜0.05或0.01）.结论 PR阴性并且p53、Ki-67、MYC高表达的脑膜瘤易复发及恶变.

Objective To determine the expressions of progesterone receptor （PR）, estrogen receptor （ER）, androgen receptor （AR）,P53,Ki-67, MYC and vascular endothelial growth factor （VEGF） in human meningioma tissue and to investigate its significance. Methods The expressions of PR,ER,p53,AR,Ki-67,MYC and VEGF were detected on microarrays by Immunohistochemistry in 64 tissue specimens of meningioma. Results The expressions of PR,VEGE,p53,Ki-67 and MYC proteins were correlated with the malignancy degree of meningioma （P〈0.05 or P〈0.01）. There were significant differences in expression rates of PR,AR,p53,Ki-67and MYC between recurrent and nonrecurrent meningioma （P〈0.01 or P〈0.05）. Conclusion Meningioma with high expression of p53, Ki-67, MYC and negative expression of PR shows high degree of malignancy and is more likely to relapse.