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肿瘤坏死因子-α抑制剂治疗强直性脊柱炎合并HBV感染的安全性分析 被引量：1

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摘要 我国HBV感染患者众多,而激素和免疫抑制剂可使HBV复制增加,甚至引起病毒血症.TNF-α抑制剂对风湿性疾病如类风湿关节炎、强直性脊柱炎（AS）有显著疗效,但同时会增加HBV复制的风险.目前由于缺乏有关TNF-α抑制剂在HBV感染患者应用的大规模安全性对照研究,其长期使用的安全性尚不明确.本文对宁波市第一医院2007年1月至2010年6月应用TNF-α抑制剂治疗的7例AS合并HBV感染的患者作一回顾分析,并结合国内外有关文献,评价TNF-α抑制剂用于此类患者的安全性及预防性抗HBV治疗的价值.
作者 周丽 忻霞菲 吴华香
机构地区 浙江大学医学院附属第二医院风湿科 宁波市第一医院风湿科
出处 《浙江医学》 CAS 2012年第12期1028-1030,共3页 Zhejiang Medical Journal
关键词 HBV感染患者 抗HBV治疗 肿瘤坏死因子-α抑制剂 安全性分析 强直性脊柱炎 TNF-Α抑制剂 宁波市第一医院 HBV复制
分类号 R512.62 [医药卫生—内科学]
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参考文献9

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二级参考文献15

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引证文献1

浙江医学
2012年 第12期

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