微量脂微球载体前列腺素E_1静注治疗慢性重度乙型肝炎疗效观察

Intravenous Micro-dose Prostaglandin E_1 Corporated in Lipid Microspheres is Better than Radix Salviae Miltionrrhizae Compound Injection Drip in treating Serious Chronic Hepatitis B

目的：观察并比较微量脂微球载体前列腺素Ｅ１（Ｌｉｐｏ ＰＧＥ１）与丹参注射液治疗慢性重度。型病毒性肝炎的疗效。方法：慢性重度乙肝４０例分２组，每组各２０例。ＰＧＥ１组（男性１５例，女性５例；年龄３６±９岁）用脂微球载体前列腺素 Ｅ１ １０ ｕｇ加入生理盐水 １０ ｍｌ中静推， ｑｄ ｘ ２０天；复方丹参组（男性 １６例，女性 ４例；年龄 ３９± ７岁）用复方丹参注射液 １６ ｍｌ加入 ５％ＧＳ ３００ ｍｌ中静滴，ｑｄ × ２０天。结果：ＰＧＥ１组与复方丹参组治疗后 ＳＴＢ、ＡＬＴ、ＡＳＴ降幅无显著差异（Ｐ＞０．０５）。但治疗总有效率ＰＧＥ１组为９０％，复方丹参组为７５％（Ｐ＜０．０５）。结论：微量脂微球前列腺素Ｅ１治疗慢性重度乙肝优于复方丹参。

Objective: To investigate and compare the effect of injection of microdosage prostaglandin E1 corporated in lipid microspheres (Lipo PGE1 ) and Radix (RSM ) compound in treatment of the serious chronic hepatitis B. Methods: Forty patients with serious chronic hepatitis B were randonly divided into two groups, each with twenty patients. The patients in Lipo PGE1 group were treacted by injection Lipo PGE1 10 ug in 0.9% sodium Chloride 10 ml, iv, qd for 20 d. The patients in RSM group were treated by RSM compund 16 ml in 5% glucose injection 300 ml iv, drip qd for 20 d. Results: No sihnficant difference were found betWeen two groups in the decrease of serum total hilirubin(STB), alanine transaminase (ALT), and aspartate transaminase (AST) (P > 0. 05). The total effective rate were 90% and 75% respective (P < 0. 05). Conclusion: The efficacy of Lipo PGE1 is better than RSM compound in treatment of the serious chronic hepatitis B.