脑血管病患者血小板膜糖蛋白CD_(62P)、CD_(63)的变化

Change and clinical significance of platelet surface glycoproteins CD 62P,CD 63 in patients with cerebrovascular disease

目的 :探讨CD62P 和CD63 与脑血管病发生发展的关系。方法 :应用流式细胞术、以单克隆抗体作分子探针 ,检测脑血管病患者248例及正常对照者38例外周血CD62P 和CD63 的变化。结果 :脑血管病组与正常对照组差异有高度显著意义(P<0.01) ,脑血管病不同病程的差异有显著意义(P<0.05) ,不同病变部位的差异无显著意义。结论 :检测脑血管病患者CD62P、CD63 的变化对诊断、治疗和预防有重要意义。

Objective: To study the relationship and clinical significance between the platelet surface glycoproteins CD 62P,CD 63 and the cerebrovascular disease.Methods:Platelet surface glycoprotein CD 62P,CD 63 in 248 patients with cerebrovascular disease and 38 normal person were measured by flow cytometry and monoclonal antibody.Results:The concentration of CD62P,CD63 in plasma in acute phase of cerebrovascular disease was elevated significantly as compared with that of controls (P<0.01).The difference was significant in acute and relief phases(P<0.01).However the difference was not significant in different position of cerebrovascular disease.Conclusion:The measurement of platelet surface glycoprotein CD 62P,CD 63 molecules in plasma has important help to diagnosis ,treatment,prevention of cerebrovascular disease.