前列地尔对老年椎基底动脉供血不足伴颈动脉斑块的疗效观察

Observation on curative effect of Alprostadil for senile vertebrobasilar insufficiency with carotid artery plaque

目的观察前列地尔对老年椎基底动脉供血不足(VBI)伴颈动脉斑块的疗效。方法将60例椎基底动脉供血不足伴颈动脉斑块形成的老年患者,随机分为观察组(前列地尔加常规治疗)和对照组(常规治疗),疗程15 d,对比观察疗效。结果与对照组比较,观察组VBI的治愈率明显提高(P<0.05),3 d显效率明显增加(P<0.05),半年内复发率显著降低(P<0.01)。治疗后,观察组颈动脉IMT变薄、斑块面积缩小,而对照组无明显变化,两组疗效差异有统计学意义(P<0.05)。结论前列地尔治疗老年VBI伴颈动脉斑块疗效高,并可改善动脉粥样硬化,缩小斑块面积。

Objective To observe the curative effect of Alprostadil on the senile vertebrobasilar insufficiency （VBI） with carotid artery plaque patients. Methods Sixty cases with VBI and carotid artery plaque were randomly divided into the observation group （ given Alprostadil combined with general therapy） and control group （ general therapy）. After the treatment course of 15 days, observe the curative effects comparatively. Results Comparing with the control group, the cure rate of observation group was obviously increased （ P 〈 0.05 ） , the evident effective rate in 3 days was obviously raised （ P 〈 0.05 ） , and the recurrence rate within half a year was remarkably decreased （ P 〈 0.01 ）. After treatment, the carotid IMT of the observation group was thinner and the carotid artery plaque area of the observation group reduced, while there is no significant change in the control group, the different of cura- tive effects of two groups showed statistical significance （ P 〈 0.05 ）. Conclusion Alprostadil has good effect on treating senile VBI with carotid artery plaque. It can improve the carotid atherosclerosis and reduce the plaque area.