溶栓胶囊对进藏新兵血氧饱和度的影响

Effect of thrombolytic capsule on blood oxygen saturation of recruits in Tibet

目的探讨溶栓胶囊对急速进入高原人群血氧饱和度(SaO2)的影响,了解药物对急性高原缺氧的预防效果。方法将330名进藏新兵按双盲法随机分为三组,溶栓胶囊组110名设为A组,进入高原前后7 d口服溶栓胶囊;红景天组110名设为B组,进藏前后7天服用红景天胶囊;医用淀粉胶囊组110名设为C组,进入高原前后7 d口服医用淀粉胶囊;测定进藏前后SaO2变化情况,并进行比较。结果溶栓胶囊和红景天胶囊均能够提高进藏人群的SaO2,与医用淀粉胶囊组的SaO2存在明显差异,但均不能达到进藏前水平。结论溶栓胶囊可适当提高进入高原人群的SaO2,从而发挥预防急性高原缺氧的作用。

Objective To evaluate the effect of thrombolytic capsule on SaO2 of recruits which entry into Tibet rapidly, and to study the prophylactic effect of medication on acute mountain sickness （AMS）. Methods Three hundred and thirty recruits entry into Tibet were divided into group A, B and C by double blinded method. Group A contained 110 members, given thrombolytic capsules from 7 days before entry into Tibet to 7 days after the entrance. Group B contained 110 members, given Rhodiola Rosea capsules during the same period. Group C contained 110 members, given starch capsules during the period. The SaO2 was measured before and after their entrance into Tibet. The results were compared with each other. Results Thrombolytic capsule and Rhodiola Rosea capsule can both raise the SaO2 of people who entry into Tibet, showed significant difference in the comparison with the SaO2 of people taking starch. However, the two capsules could not raise the SaO2 to the level before entering Tibet. Conclusion Thrombolytic capsule can raise the SaO2 of people entry into Tibet to a certain level, which can prevent AMS.