药物外排泵基因表达与结核分枝杆菌耐药关系分析

Relationship between Drug Efflux Pump Gene Expression and the Drug Resistance of Mycobacterium Tuberculosis

目的了解药物外排泵基因表达与结核分枝杆菌耐药性之间的关系,为结核病患者寻找到新的治疗药物提供有效的医学理论依据。方法选择本地区结核病防治所的结核病采样190例,随机分为两组,对照组95例做常规治疗,观察组95例通过药物外排泵进行治疗,在两组临床资料中进行对比分析。结果观察组的耐药程度明显低于对照组,差异均有统计学意义(P<0.05)。观察组治疗后结核病人的药物吸收状况、症状的好转程度明显优于对照组,差异具有统计学意义(P<0.05)。结论通过药物外排泵的基因表达来分析结核分枝杆菌的耐药性能高低,研究出更加科学、合理的结核病防治措施,减少结核病的传染频率,提高医学对症治疗手段。

Objective To evaluate the relationship between drug efflux pump gene expression and the drug resistance of mycobacterium tuberculosis. Methods 190 patients with tuberculosis were randomly divided into two group. In control group, the patients received routine treatment, while the patients in observational group were treated with efflux pump gene based drugs. Results The drug resistance rate was lower in observational group than that in control group. The degree of absorption of drug and improvement in symptoms was better in observational group than that in control group. Conclusion anti -tuberculosis drug treatment.