氟西汀与丙咪嗪治疗抑郁症的对照研究

A comparative study of efficancy of fluoxetine and imipramine in treatment of depressive disorder

目的 比较氟西汀与丙咪嗪治疗抑郁症的疗效及不良反应。方法 采用随机分组对照研究的方法 ,分为氟西汀组 2 8例 ,予氟西汀 2 0mg·d-1;丙咪嗪组 2 7例 ,予丙咪嗪 15 0mg·d-1;6wk为一疗程。结果 氟西汀组有效率 92 .9% ,丙咪嗪组 92 .6 % ,经卡方检验P >0 .0 5。药物不良反应发生率丙咪嗪组高于氟西汀组。结论 氟西汀的抗抑郁作用与丙咪嗪相当 ,副作用少 ,服用方便。

Objective To compare the effects and side reactions of fluoxetine and imipramine in treatment of depressive disorders. Method Fifty-five patients with depressive disorder were divided randomly into 2 groups: 28 patients were treated with fluoxetine, 20mg·d -1 for 6wk; 27 patients were treated with imipramine, 150mg·d -1 for 6wk. Result The total clinical effective rates were 92.9% in fluoxetine group and 92.6% in imipramine group(P>0.05). The side reactions in imipramine group was highter than in fluoxetine group. Conclusion Fluoxetine showed the same effects but less side reaction than imipramine