汉防己甲素和六味地黄丸联合治疗矽肺的临床疗效观察

Hangfangchin A and Liuwei Dihuang Wan in the treatment of silicosis

本文报道了汉防己甲素和中药六味地黄丸联合治疗矽肺的临床疗效观察。结果表明,汉防己甲素100mg,Bid,六味地黄丸8g,Bid,每周同服6天,连服6个月,使矽肺病人咳嗽、咳痰、胸痛、呼吸困难4项临床症状明显改善(P<0.05)。特别是对咳嗽、咳痰有显著治疗作用,改善率达94.1％(P<0.01)。感冒和支气管肺部感染频率下降52.94％,有统计学意义(P<O.05)。治疗组和对照组在治疗前后肺功能(FVC、FEV_(1.0))均为稳定状态(差值变化不足10％),这有待进一步临床观察。采用中西药联合治疗矽肺的方法有利于提高药物疗效,减轻病人临床症状,发扬光大祖国传统医药学,值得推广使用。

Therapeutic observation on hangfangchin A and Liuwei Dihuang Wan in the treatment of silicosis is reported in this article. The result shows that after taking hangfangchin A 100mg, Bid and Liuwei Dihuang Wan 8g, Bid for 6 months ( 6 days per week), four clinical symptoms of silicosis patients (cough, expecoration, pectoralgia and dyspnea) are improved obviously (p < 0.05) . Especially improvement rate on cough and expecoration amounts to 94.1 % (p < 0.01). Frequency rate of common cold and bronchopulmonary infection drops 52.94 % . Pulmonary functions of treatment group and control group are both in steady state before and after treatment, but it needs further clinical observation. Treating silicosis by combination of Chinese and western drug is helpful for raising drug effect, releasing clinical symptoms of patients, and developing traditional Chinese medicine and pharmacy.