血液病患者中庚型肝炎病毒检测及感染情况研究

Hepatitis G Virus Detection and Infection in Various Forms of Blood Disease

目的:了解武汉地区血液病患者中庚型肝炎病毒(HGV)的感染情况,探讨HGV的传播途径。方法:采用酶联免疫吸附试验(ELISA)及逆转录聚合酶链反应(RT-PCR)方法测定各型血液病患者血清中的抗HGV和HGV RNA。结果:51例血液病患者中血清抗HGV阳性6例,占11.8％(5/61),HGV RNA均阴性。6例抗GHV阳性患者中急粒2例,占25%(2/8),慢粒1例,占50%(1/2),再障2例,占50％(2/4),粒细胞缺乏症1例,占100%(1/1)。6例抗HGV阳性患者均有受血史,占18.7%(6/32),显著多于无受血史者。6例抗HGV阳性患者有1例ALT升高,且发生在化疗结束后,与抗HGV阴性患者无显著性差异。结论:血液病患者中存在HGV感染,输血是其主要传播途径,且与受血次数呈正相关。HGV病毒血症时间短,为自限性,致病力弱,不单独引起肝损害,也不加重化疗所致的肝损害。

Aim: To evaluate the prevalence and significance of HGV infection in various forms of blood disease and inquire into the transmission of HGV in Wuhan arear. Methods: HGV antibody and HGV RNA in serum were detected respectively by ELISA and RT-PCR. Results: HGV-Ab was positive in 6 of 51 patients with blood disease (11.8 % ) and among them zero were positive with HGV RNA. HGV-Ab positive rates were 25% (2/8) acute granulocytic Leukemia, and 50% (1/2) in chronic granulocytic Leukemia. 50% (2/4) in aplastic anemia, 100% (1/1) agranulocytosis. The 6 cases with positive serum all have history of accepting blood products. The ratio was 18. 7% (6/32). The difference between them and patients who have no history of accepting blood products being significant. Among 6 cases with positive serum, only 1 patients have liver damage (SALT was higher than normal). This occurred often the end of chemo therapy and have no difference with negative cases. Conclusion: HGV infection exists in blood disesae. Blood transmission is the main route of HGV infection, and have positive relationship with the number of accepting blood products. Pathogenicity of HGV is slight. HGV can not cause liver damage alone, and can not make liver damage caused by chemo therapy worse.