IFN-α治疗慢性乙型肝炎抗病毒疗效与血清IL-6变化的关系

Study on the Relation between Changes of IL-6 in Serum in Patients with Chronic Hepatitis B and Action of Treatment with IFN-α

目的:观察慢性乙型肝炎患者经α-干扰素(IFN-α)抗病毒治疗前后血清白细胞介素-6(IL-6)水平的变化与乙肝病毒消长之间的关系。方法:收集治疗前后血清标本—20C保存,通过ELISA法同步检测并与正常人做对照。结果:治疗前病人组血清中IL-6水平均较正常组高,尤其IFN-α治疗有效应答组增高明显。经IFN-α治疗的有效应答组IL-6水平较治疗前明显下降。结论:IFN-α除本身有抑制病毒复制外,通过免疫调节对病毒复制影响也具有重要作用。

Aim: To investigate the relationship between the changes of interleukin-6 (IL-6) in serum from patients (25) with chronic hepatitis B (CHB) and antiviral action of IFN-α. Methods: Using ELISA for detection of IL-6 level change in serum of patients with CHB before and after IFN-α treatment. Results: Our date showed that the level of IL-6 in patients increased significantly as compared with normal subjects (P<0. 01), but the level in patients (10) with response to IFN-α treatment was significantly higher than that in nonresponse (15) (P<0. 01) , the IL-6 level after IFN-αtreatment was significantly lower than that before in response patients (P<0. 05). Conclusion: The results suggested that the immunoregulation of IFN-aaaaaaaa can play an important role in process of inhibiting HBV replication.