大黄(庶虫)虫丸防治非酒精性脂肪性肝炎的实验研究

Effect of Dahuang Zhechong Pills in the Prevention and Treatment of Nonalcoholic Steatohepatitis (NASH) in Rats

目的:观察大黄(?)虫丸对高脂饮食诱发的肥胖性高脂血症性脂肪性肝炎动物模型形成的影响。方法:29只SD大鼠随机分3组:正常组(n=9)普通饲料喂养;模型组(n=10)为高脂饲料喂养;大黄(?)虫丸组在高脂饲料喂养2周后予大黄(?)虫丸10.8g/kg.d水溶液为唯一饮料。观察一般情况及血清肝功能、血脂,并行病理学检查。结果:与模型组相比,大黄(?)虫丸组的体重、肝指数、血TCH、FFA及血清转氨酶均呈下降趋势。病理学检查示大黄(?)虫丸组肝脏脂肪变及炎症活动度无任何改善,且有2例分别出现了轻度和中度的碎屑样坏死。结论:大黄(?)虫丸虽在一定程度上能改善肥胖性高脂血症脂肪性肝炎的生化指标,但它不能减轻肝组织学病变。

Aim: No established treatment exists for non-alcoholic steatohepatitis (NASH), so the goal of this experiment was to evaluate the efficacy of Dahuang Zhechong pills in the prevention of NASH in rats induced by high-fat diet. Method: 29 male SD rats were divided into 3 groups at random, i. e. standard diet (group Ⅰ); high fat diet (group Ⅱ ) and high fat diet plus Dahuang Zhechong pills (group Ⅲ). Rats were killed at 12 weeks after experiment. The following were detected in each groups: the serum lipid .aminotransferase values and liver pathology. Result: Dahuang Zhechong pills group;have a trend toward a reduction in lowing weight,liver index,serum lipid and aminotransferase activity. However all the differences were not significant in statistics. Little improvement in some histological features such as steatosis and inflammation were oberserved. Conclusion: Despite the benificial effect of Dahuang Zhechong pills in liver cirrhosis, it did not appear to he of benefit in the treatment of NASH.