摘要
目的:为研究酒精性肝病(ALD)提供理想的动物模型。方法:模型组大鼠12只,采用50％酒精每日2次灌胃,同时给予酒精饮料饲养,连续14周,建立慢性酒精性肝损伤大鼠模型;应用光镜和电镜观察酒精对大鼠肝组织及超微结构的影响。结果:模型组所有大鼠均出现了脂肪肝;91.6％的动物发生了酒精性肝炎,部分大鼠(16.7％)可见肝脏间质反应性增生;对照组大鼠肝组织及超微结构均正常。结论:该方法可造成具有类似于人类ALD病理改变的大鼠模型。
Aim: To provide an ideal animal model of ALD in rat. Method: The chronic ALD was modelled in 12 rats, by means of gastrolavaging 50% alcohol twice a day and feeding alcohol beverage during 14 weeks. As the control group (12 rats), water instead of alcohol was gastrolavaged and fed in the same one. Then the pathologic change of hepatic tissue in both groups was observed respectively in light microscope and electronic microscope. Results: In the model group. all the rats appeared fatty liver. 91. 6% arised alcoholic hepatitis. 16. 7% showed reactive hepatic interstitial proliferation; No pathologic change was found in the control group. Conclusion: The modelling in rat was proved successful,which high similar to the chronic ALD in human.
出处
《中西医结合肝病杂志》
CAS
2000年第2期30-31,共2页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
关键词
酒精性肝病
大鼠模型
病理学
Alcoholic Liver Disease (ALD) Animal Model, Rat Pathology
