二硫化碳作业女工受孕能力的前瞻性研究

A prospective study on the pregnancy potential among female workers exposed to carbon disulfide

目的 确证回顾性研究发现二硫化碳 (CS2 )作业女工受孕能力受抑的现象 ,并探讨“受孕时间”作为标志生殖损伤筛选指标的可行性。方法 在回顾性研究现场对欲生育的女工受孕时间进行了前瞻性研究。结果 ( 1)2 5 7名接触组女工第一个月经周期受孕率为 2 7 2 % ,前三个月经周期累积受孕率为 5 8 7% ,一年内累积受孕率为93 7% ,均明显低于对照组 (分别为 3 5 8%、 69 1%和 97 0 % ,P值分别为 0 0 181、 0 0 0 40和 0 0 14 5 ) ;( 2 )仅女方接触或夫妻双方接触CS2 组的受孕率均低于夫妻双方均不接触CS2 的受孕率 ;夫妻双方接触与单纯女工接触CS2 ,受孕率无明显差异 ;( 3 )每名女工受孕时间与其接触CS2 浓度 (r =0 1198,P =0 0 2 4)及接触时间 (r =0 2 799,P =0 0 0 0 )呈正相关。结论 受孕时间可作为标志生殖损伤效应的初筛指标。

Objective To verify the phenomenon of reduced pregnancy potential in female workers exposed to carbon disulfide(CS 2)found in retrospective study before.Method Following up each subject to survey that how many menstral cycles needed for pregnancy.Results (1)The pregnancy rates of 257 CS 2 exposed female workers in first menstral cycle was 27 2% and 35 8% in 366 control female workers.The cumulative pregnancy rate in first three menstral cycles was 58 7% for CS 2 exposed group and 69 1% for the control and the tatal pregnancy rate in one year for CS 2 exposed group was 93 7% and 97 0% for control.There were significant differences between two groups(P value were 0 0181,0 0040,and 0 0145,respectively).(2)The pregnancy rates were lowered when women or couples exposed to CS 2 comparing with that of the control couples,but there was no difference between women exposed group and couple exposed group.(3)There was positive correlation between pregnancy time and her exposed concentration of CS 2(r=0 1198,P=0 024),and her standing age exposed to CS 2(r=0 2799,P=0 000).Conclusion Pregnancy time may be a useful indicator as a primary screening index for monitoring reproductive damage.