血管性血友病因子、抗凝血酶Ⅲ及D-二聚体与急性白血病关系的研究进展

Research evolution of relationship between DD, vWF, AT-Ⅲ and acute leukemia

急性白血病（AL）患者血管内皮受损，体内存在凝血与纤溶异常，而造成其凝血功能障碍，可能表现为高凝状态或血栓形成，发生率约10％～40％，多出现于疾病的早期、化疗或合并感染之后，临床上可无明显的症状及体征，且常规的凝血指标也很难检测到这种高凝状态。因此动态监测血浆血管性血友病因子（vWF）、抗凝血酶Ⅲ（AT-Ⅲ）、D-二聚体（DD）含量可为临床凝血功能障碍的早期诊断和防治提供理论依据。

The injury of vascular endothelium, activation of coagulation and exist of fibrinolysis in patients with acute leukemia caused the coagulation disorders. It would appear hypereoagulation status or thrombosis, and the incidence was about 10 %- 40 %. It appeared in the early phase of this disease, chemotherapy or infection, and may have no clinical symptoms or signs. The routine coagulation index was also very diffcuh to detect this hyper coagulation state. Therefore, monitoring in different phrase the content of plasma AT-Ⅲ , vWF and DD in acute leukemia provided the evidence for early diagnosis, prevention and cure of acute leukemia.