原发性血小板增多症血清糖酵解酶乳酸脱氢酶及神经元特异性烯醇化酶水平变化的临床观察

Clinical observation of serum glycolytic enzyme lactate dehydrogenase and neuron-specific enolase levels in essential thrombocythemia

目的:探讨原发性血小板增多症(ET)患者血清糖酵解酶乳酸脱氢酶(LDH)和神经元特异性烯醇化酶(NSE)的水平变化及临床意义。方法:采用酶法测定89例ET患者初诊时血清LDH水平,41例采用电化学发光法测定血清NSE水平,并对结果进行统计学分析。结果:89.89%患者血清LDH水平高于正常,均值较对照组明显升高(P<0.01)。87.80%患者血清NSE水平高于正常值,均值较对照组明显升高(P<0.01)。血清LDH及NSE水平均与血小板计数呈正相关(P<0.01或P<0.05)。血清LDH与NSE水平呈正相关(P<0.01)。结论:ET患者血清LDH及NSE水平升高可反映血小板的增殖程度。

Objective：To study the levels and clinical significance of serum glycolytic enzyme lactate dehydrogenase（LDH）and neuron-specific enolase（NSE）in essential thrombocythemia（ET）.Method：Serum LDH levels were measurd by enzymic method in 89 cases with ET at initial diagnosis.Serum NSE levels in 41 cases were detected by electrochemiluminescence.The results were statistically analyzed.Result：Serum LDH levels of 89.89% patients were higher than normal,the mean was significantly higher than the control group（P〈0.01）.The levels of serum NSE for 87.80% patients were higher than normal,the mean was significantly higher than the control group（P〈0.01）.Serum LDH and NSE levels were positively correlated（P〈0.01）and were positively correlated with platelet count（P〈0.01 or P〈0.05）.Conclusion：The serum LDH and NSE levels can reflect the degree of proliferation of platelets in ET.