小檗碱和二甲双胍对2型糖尿病患者血脂的影响

Effect of berberine and metformin on serum lipids of type 2 diabetes mellitus patients

目的探讨小檗碱和二甲双胍治疗对2型糖尿病患者血脂的影响。方法入选初发2剐糖尿病伴血脂异常患者50例，随机分为小檗碱组和二甲双胍组，治疗随访6个月，治疗前后测定患者血脂、血糖、胰岛素和糖化I衄红蛋白（HbA1c）等指标。结果治疗6个月小檗碱组和二甲双胍组患酱总胆固醇（Tc）、低密度脂蛋白-胆固醇（LDL—C）、甘油三脂（TG）均明显降低（P〈0．05），组间比较斧异无统计学意义。两组HbA1c、胰岛素抵抗指数（HOMA—IR）和胰岛8细胞功能指数（HOMA—β）均明姓改善，二甲双胍组改善HOMA—IR较小檗碱组明显（P〈0．05）。结论小檗碱可能通过多种机制降糖降脂，对伴有血脂异常的2型糖尿病患者小檗碱效果可能优于二甲双胍。

Objective To evaluate the effect of berberine（BBR） and metformin（MF） on hyper- lipemia of type 2 diabetes（T2DM） patients. Methods The fifty newly diagnosed T2DM patients with hy- perlipemia were randomly assigned to receive BBR or MF. Followed to treat 6 month, the serum lipids, plasma glucose concentration,insulin and glycated hemoglobin（HbAlc） were detected uniformly. Results At the end of 6 month treatment, total cholesterol （ TC）, low-density lipoprotein-cholesterol （ LDL-C ）, triglycerides（TG） were significantly decreased （P 〈 0.05 ）, but it was no siginificant difference between BBR group and MF group. HbAlc, homeostasis model assessment evaluated for insulin resistance （HOMA-IR） and insulin secretion （HOMA-β） levels were siginificant improved in both groups, HOMA-IR was more siginificant improved in MF group than BBR group（P 〈 0.05）. Conclusion Ber- berine moderates glucose and lipid metabolism through muhipathway mechanism. Perhaps it＇ s better than MF on sermn lipids of T2DM patients.