热休克蛋白70与肝肠钙黏连蛋白在胃腺癌中的表达及其临床意义

The expression of HSP70 and LI-cadherin in gastric adenocarcinoma

目的探讨热休克蛋白70（HSP70）与肝肠钙黏连蛋白（u—cadherin）在胃腺癌中的表达及其与胃腺癌生物学行为的关系。方法采用免疫组化sP法检测60例胃腺癌组织中HSP70和LI—cadherin的表达，并分析两种蛋白表达的相关性。结果HSP70在胃腺癌患者中的表达率为71．67％（43／60）；在低分化胃腺癌患者的表达强度高于高分化型（P〈0．05）；伴有淋巴结转移的胃腺癌患者其表达率高于无淋巴结转移者（P〈0．05）。LI—cadherin在胃腺癌患者中的表达率为58．33％（35／60）；在高、中型分化胃腺癌的表达高于低分化型，差异有统计学意义（P〈0．05）。HSP70与LI-cadherin在胃腺癌中的表达呈正相关，相关系数为（r=0．449，P〈0．05）。结论HSP70与LI—cadherin和胃癌分化程度密相关，且两者在胃腺癌中的表达具有相关性，提示两种蛋白与胃腺癌发展密切相关。

Objective To detect the expression of heat shock protein 70（HSP70） and liver-intes- tine cadherin（LI-cadherin） in gastric adenocarcinoma and explore the interaction between the two pro- teins. Methods The expression of HSP70 and LI-cadherin were detected by immunohistochemistry meth- od in 60 gastric adenocarcinoma patients, and the correlation of the two proteins were analyzed. Results The positive rate of HSP70 was 71.67% in gastric adenocarcinoma, and it was higher in the cases with undifferentiated type and lymph node metastasis than those with differentiated type and without lymph node metastasis（ P 〈 0.05 ）. The expressions rate of LI-cadberin was 58.33% , and it was higher in the well-differentiated tissues than that in low-differentiated tissues. A positive correlation was found between HSPT0 and LI-cadherin（r = 0. 449, P 〈 0.05 ）. Conclusion A consistent expression and correlation are presented between HSP70 and LI-cadherin and the two proteins are closely associated with the infiltration and transferring of the gastric adenocarcinoma.