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肿瘤转移抑制基因Nm23的作用机制及临床应用研究进展 被引量：1

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摘要 1988年,Steeg等分离鉴定出一种新的肿瘤转移抑制基因,即Nm23基因.Nm23是第一个被发现抑制肿瘤转移的基因,其表达与数种肿瘤的转移潜能病理学指标、淋巴结浸润及不良预后有关[1].该基因的蛋白产物为核苷二磷酸激酶（NDPK）,是一种由数个16~20 kD的多肽组成的70~100 kD的蛋白质.
作者 杨春晓 张玉 师少军
机构地区 华中科技大学同济医学院附属协和医院药剂科
出处 《中国药师》 CAS 2012年第6期783-787,共5页 China Pharmacist
基金 湖北省自然科学基金资助项目(编号:2009CDB380) 中央高校基本科研业务费专项资金资助项目(编号:2011JC039)
关键词 NM23 肿瘤转移抑制基因 核苷二磷酸激酶
分类号 R730.54 [医药卫生—肿瘤]
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参考文献27

  • 1Bilitou A,Watson J,Gartner A,et al.The Nm23 family in development[J].Mol Cell Biochem,2009,329(1-2):17-33.
  • 2Boissan M,Dabernat S,Peuchant E,et al.The mammalian Nm23/NDPK family:from metastasis control to cilia movement[J].Mol Cell Biochem,2009,329(1-2):51-62.
  • 3Desvignes T,Pontarotti P,Fauvel C,et al.Nme protein family evolutionary history,a vertebrate perspective[J].BMC Evol Biol,2009,9:256.
  • 4Bosnar MH,Bago R,Cetkovic H,et al.Subcellular localization of Nm23/NDPK A and B isoforms:a reflection of their biological function[J].Mol Cell Biochem,2009,329(1-2):63-71.
  • 5Steeg PS,Horak CE,Miller KD.Clinical-Translational Approaches to the Nm23-H1 Metastasis Suppressor[J].Clin Cancer Res,2008,14(16):5006-5012.
  • 6Li J,Zhou J,Chen G,et al.Inhibition of ovarian cancer metastasis by adeno-associated virus-mediated gene transfer of Nm23-H1 in an orthotopic transplantation model[J].Cancer Gene Ther,2006,13(3):266-272.
  • 7Marshall JC,Collins J,Marino N,et al.The Nm23-H1 metastasis suppressor as a translational target[J].Eur J Cancer,2010,46(7):1278-1282.
  • 8Srivastava S,Li Z,Ko K,et al.Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of K3.1 and CD4 T cells[J].Mol Cell,2006,24(5):665-675.
  • 9Di L,Srivastava S,Zhdanova O,et al.Nucleoside diphosphate kinase B knock-out mice have impaired activation of the K+ channel KCa3.1,resulting in defective T cell activation[J].J Biol Chem,2010,285(50):38765-38771.
  • 10Murakami M,Menses PI,Knight JS,et al.Nm23-H1 modulates the activity of the guanine exchange factor Dbl-1[J].Int J Cancer,2008,123(3):500-510.

同被引文献23

  • 1Steeg PS, Bevilacqua G, Kopper L, etal. Evidence for a novel gene associated with ]ow tumor metastatic potential [J]. J Natl Cancer Inst, 1988, 80 (3) .. 200-204.
  • 2Marino N, Nakayama J, Collins JW, et al. Insights into the biology and prevention of tumor metastasis provided by the Nm23 metastasis suppressor gene [J]. Cancer Metastasis Rev, 2012, 31 (3-4) .. 593-603.
  • 3Prabhu W, Siddikuzzaman, Grace VM, et al. Targeting tumor metastasis by regulating Nm23 gene expression [J]. Asian Pac J Cancer Prev,2012, 13(8) :3539-3548.
  • 4Fotoohi AK, Coulthard SA, Albertioni F. Thiopurines: Fac- tors influencing toxicity and response [J]. Biochem Pharrna- col,2010, 79(9) :1211-1220.
  • 5Karner S, Shi S, Fischer C, et al. Determination of 6-thio- guanosine diphosphate arn:t triphosphate and nucleoside diphos- phate kinase activity in erythrocytes: novel targets for thiopu- rine therapy? [J]. Ther Drug Monit,2010, 32(2):119-128.
  • 6Braunagel D, Schaich M, Kramer M, et al. The T_T geno- type within the NME1 promoter single nucleotide polymor- phism - 835 C/T is associated with an increased risk of cytara- bine induced neurotoxicity in patients with acute myeloid leu- kemia[J]. Leuk Lymphoma,2012, 53(5) :952-957.
  • 7Nordgard SH, Alnaes GI, Hihn B, etal. Pathway based anal-ysis o SNPs with relevance to 5-FU therapy: relation to intra- tumoral mRNA expression and survival [J]. Cancer, 2008, 123(3) :577-585.
  • 8Daly AK. Genetic polymorphisms affecting drug metabolism: recent advances and clinical aspects [J]. Adv Pharmacol, 2012, 63:137-167.
  • 9Bakhouche H, Slana} O. Pharmacogenetics in clinical practice [J]. Prague Med Rep,2012, 113(4) :251-261.
  • 10Qu S, Long J, Cai Q, et al. Genetic polymorphisms of metas- tasis suppressor gene NME1 and breast cancer survival [J]. Clin Cancer Res,2008, 14(15) :4787-4793.

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中国药师
2012年 第6期

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