兰索拉唑联合二联抗生素治疗消化性溃疡46例临床分析

Effect of lansoproazole combined with two other antibiotics on digestive ulcer

目的探讨兰索拉唑联合二联抗生素阿莫西林和克拉霉素治疗消化性溃疡的临床效果。方法选取94例2009年6月~2010年6月收治的消化性溃疡患者,随机分为治疗组和对照组,对照组48例,治疗组46例,对照组患者给予法莫替丁＋阿莫西林胶囊＋克拉霉素片＋麦滋林治疗;治疗组患者给予兰索拉唑＋克拉霉素＋阿莫西林胶囊＋麦滋林治疗,以7d为一疗程,共2个疗程。观察比较两组治疗效果及不良反应的发生率。结果治疗组总有效率达到97.8%,对照组的总有效率达到87.5%,两组差异具有统计学意义（P〈0.05）,两组患者均未出现肝肾功能损害现象,不良反应发生率也较低。停药后不良反应的现象均消失。结论兰索拉唑作为一种新型的质子泵抑制剂,其抑酸效果强大而持久,其配合二联抗生素克拉霉素和阿莫西林治疗消化性溃疡效果显著,比法莫替丁等H2受体疗效更为显著,且用药安全性高,值得借鉴。

Objective To observe the efficacy of lansoprazole in combination with amoxicillin in treatment of digestive ulcer.Methods The 94 digesetive ulcer patients were srandomly divided into treatment group consisted of 48 cases and control group consisted of 46 cases.The patients in control group were orally given 200 mg of famotidine,amoxicillin,clarithromycin,marzulene.The patients in treament group were trerated with lansoprazole,clarithromycin,amoxicillin and marzulene,7 day a course for 2 courses.Results The total effeciive rates were 97.8% and 87.5% in the treatment group and control group,showing significant differences（P〈0.05）.No hapatic and renal lesions were observed and the aide effect rate was low in the two groups.Conclusion Lansoprazole is a novle proton pump inhibitor and it is,in combination with clarithromycin and amoxicillin,is effective for treatment of digestive ulcer and safe.