颅脑火器伤时血浆心房肽浓度变化及其意义探讨

The changes of plasma atriopeptins in dog with bullet wound on head

本实验观察以7.62mm 制式弹丸致伤犬额部伤前和伤后2.5小时静脉血浆心房肽浓度的变化,同时测定颅内压。发现伤后2小时血浆心房肽由伤前的53.51±3.61Pg/ml 下降到31.28±5.86Pg/ml,5小时下降到13.35±1.75Pg/ml。血浆心房肽下降的同时,颅内压急剧上升,伤后5小时为伤前的8倍。实验结果提示,颅脑火器伤治疗,采用适当心房肽可能对改善脑组织心房肽代谢,降低颅内压有关系。

The changes of venous plasma atriopeptin andintracranial pfressure were observed in dogs with dul-let wound over frontroparietal region.It was foundthat the plasma atriopeptins was 53.31±3.61pg/ml be-fore wounding and droped to 31.28±5.86pg/ml at2 hours,then to 13.35±1.75pg/ml at 5 hours afterwounding.In the meantime,the intracranial pres-sure marked increased and was 8 times as high asbefore wounding.The result suggested that the atrio-peptins may be useful to improve the metabolismof the brain atriopeptins and decrease the intracranialpressure.