摘要
目的建立人胎盘脂多糖注射液生物活性测定方法。方法从致敏剂量确定动物模型,从不同给药剂量、不同给药时间、不同攻击时间对生物活性测定方法进行研究。结果用牛白蛋白50mg.mL-1致敏后,人胎盘脂多糖注射液2.0mL.只-1给药9次,可显著减少过敏反应的发生。结论本品具有抗过敏作用,可用生物活性测定方法控制其质量。
Objective To determine the bioactivity of human placental lipopolysaccharide injection. Methods Animal model was built with different induction doses, delivery doses, delivery time and attacking time. Results Bovine albumin （50 mg·mL-1） was induced and human placental lipopolysaccharide injection was given 9 times, which significantly reduced the allergic reactions. Conclusion The bioactivity assay of human placental lipopolysaccharide injection can be used for the quality control.
出处
《中南药学》
CAS
2012年第6期440-443,共4页
Central South Pharmacy
基金
长沙市科技计划重点项目(No.K0904032-11)
关键词
人胎盘脂多糖注射液
抗过敏作用
生物活性
human placental lipopolysaccharide injection
anti-allergic effect
bioactivity
