消黄饮防治母儿ABO血型不合溶血病的临床研究

Research the Clinical Prevention and Treatment of XiaoHuangyin for The ABO Maternal-Fetal Blood Group Incompatibility

[目的]观察消黄饮防治母儿ABO血型不合溶血病的临床疗效。[方法]将符合纳入标准的孕妇随机分为三组即消黄饮组、茵陈蒿汤组、西医药组,消黄饮组服用消黄饮,茵陈蒿汤组服用茵陈蒿汤,西医药组给予葡萄糖、维生素等西医综合疗法,4周为1个疗程,比较三组降低抗体效价的效率。[结果](1)综合疗效:消黄饮组治愈率69.49%,总有效率86.44%;茵陈蒿汤组治愈率46.15%,总有效率55.77%;西医药组治愈率35.09%,总有效率50.87%,消黄饮组优于茵陈蒿汤组与西医药组,有显著差异(P<0.05),而茵陈蒿汤组与西医药组比较差异无统计学意义(P>0.05)。(2)抗体效价下降率:消黄饮组81.37%、茵陈蒿汤组55.76%、西医药组52.63%,消黄饮组明显优于其他两组,有显著差异(P<0.05),茵陈蒿汤组及西医药组比较差异无统计学意义(P>0.05)。[结论]消黄饮能有效的防治母儿ABO血型不合溶血病,其疗效满意,且无明显副作用。中药方剂简单、方便、有效,对于围产期保健具有一定的临床应用意义,但其确切的机理还有待进一步研究。

[Objective] To investigate the chnical effect and security of XiaoHuangyin for the ABO maternal-fetal blood group incompatibility. [Method] We selected patients suffering from ABO maternal-fetal blood group incompatibility hemolytic disease and randomly divide them into XiaoHuangyin group, YinChenHaoTang group and west medicine group, and then observed and compared the results.[Result] 1. The total effective rate： The cure rates of the XiaoHuangyin group and the YinChenHaoTang group were 69.49% and 46.15%, the west medicine group was 35.09%. That the total effective rates of the XiaoHuangyin group and YinChenHaoTang were 86.44% and 55.77%, the west medicine group was 50.87%. And The results of the XiaoHuangyin group were better than those of YinChenHaoTang group and west medicine group, all the differences were meaningful to statistics, while the differences between matched YinChenHaoTang group and matched west medicine group sets were not meaningful to statistics. 2. Decreased rate of the blood type antibody： The all efficiency to bring down the blood type antibody of the XiaoHuangyin group was 81.37% ,while in the YinChenHaoTang group and the west medicine group was 55.76% and 52.63% respectively. The results of the XiaoHuangyin group were better than those of the YinChenHaoTang group and the west medicine group, all the differences were meaningful to statistics, while the differences between matched YinChenHaoTang group and matched west medicine group sets were not meaningful to statistics. [Conclusion] The treatment of maternal-fetal ABO blood group with XiaoHuangyin has a significant clinical effect, without adverse reaction. Chinese medicine is simple and convenient and efficient for perinatal stage care of the clinical significance, but the exact mechanism needs further study.