灌肠联合苯巴比妥对母乳性黄疸患儿体液和细胞免疫功能的影响研究

Study of the influence of enema combined with phenobarbital on humoral immunity and cellular immunity of children with breast milk jaundice

目的研究灌肠联合苯巴比妥对母乳性黄疸患儿体液和细胞免疫功能的影响。方法选取2009年2月～2012年1月我院进行治疗的64例母乳性黄疸患儿为研究对象，根据随机数字表法将其分为灌肠组（对照组）和灌肠联合苯巴比妥组（观察组），每组各32例。将两组患儿治疗后3、7、10d及10d以上的黄疸消退率、治疗前后的体液和细胞免疫功能指标进行比较。结果观察组治疗后3、7、10d的黄疸消退率明显高于对照组，而其治疗后3、7、10d的体液和细胞免疫指标改善幅度也大于对照组，差异有统计学意义（P〈0．05）。结论灌肠联合苯巴比妥对母乳性黄疸患儿体液和细胞免疫功能的影响明显，可显著改善患儿的机体免疫力。

Objective To study the influence of enema combined with phenobarbital on humoral immunity and cellular immunity of children with breast milk jaundice. Methods 64 cases of children with breast milk jaundice in our hospital from February 2009 to January 2012 were selected as research objects,and were divided into the control group （enema group） and the observation group （enema combined with phenobarbital group）, each group had 32 cases according to random number table. The regression rate of jaundice after treatment at 3, 7, 10 d and more than 10 d, functional parameter of humoral immunity and cellular immunity before and after treatment were compared. Results In the observation group, the regression rates of jaundice after treatment at 3, 7, 10 d were all significantly higher than those of the control group; the improvement range of humoral immunity and cellular immunity parameters after treatment at 3, 7, 10 d were more than those of the control group, there were all significant differences （P 〈 0.05）. Conclusion The influence of enema combined with phenobarbital on humoral immunity and cellular immunity of children with breast milk jaundice is obvious, and it can significantly improve the body immunity of children.