雌激素受体、孕激素受体在甲状腺乳头状癌中的表达及临床意义

Expression and clinical significance of estrogen receptor and progesterone receptor in papillary thyroid carcinoma

目的探讨雌激素受体(ER)、孕激素受体(PR)在甲状腺乳头状癌、甲状腺腺瘤中表达情况。方法用SABC免疫组化法检测ER、PR在164例甲状腺乳头状癌、128例甲状腺腺瘤、40例正常甲状腺组织中表达情况,并分析ER、PR的表达与甲状腺乳头状癌患者性别、淋巴转移的相关性。结果 ER、PR在甲状腺乳头状癌、甲状腺腺瘤中表达阳性率明显高于正常组织,其差异具有高度统计学意义(χ2=40.01、33.47,P<0.01;χ2=8.19、8.40,P<0.01),甲状腺乳头状癌和甲状腺腺瘤ER、PR阳性表达差异具有高度统计学意义(χ2=24.56、16.81,P<0.01)。甲状腺乳头状癌患者中淋巴转移者、无淋巴结转移者的ER、PR阳性表达差异具有高度统计学意义(χ2=18.39、8.84,P<0.01)。结论 ER、PR参与甲状腺乳头状癌的发生、发展,检测ER、PR能对甲状腺乳头状癌的早期诊断和预后提供帮助。

Objective To evaluate the expression and clinical significance of estrogen receptor （ER） and progesterone receptor （PR） in papillary thyroid carcinoma and thyroid adenom. Methods Immunohistochemistry （SABC） was used to detect the expression of ER, PR in 164 cases of papillary thyroid carcinoma,128 cases of thyroid adenoma, 40 eases of normal thyroid tissue. The correlation between expression and clinical features including histological type, gender disparity and lymphatic metastasis were analyzed. Results Compared with the normal thyroid tissue, the positive rates of ER and PR were higher in papillary thyroid carcinoma and thyroid adenoma, with statistical significance （χ2= 40.01, 33.47, P 〈 0.01; χ2 = 8.19, 8.40, P 〈 0.01）. There was significant difference of ER, PR expressions between papillary thyroid carcinoma and thyroid adenoma （χ2 = 24.56, 16.81, P 〈 0.01）. There was significant difference of ER, PR expressions between lymphatic metastasis and without lymphatic metastasis of papillary thyroid carcinoma. （χ2 = 18.39, 8.84, P 〈 0.01）. Conclusion ER and PR both contribute to the development of papillary thyroid carcinoma.