含左氧氟沙星四联方案补救治疗幽门螺杆菌52例临床分析

Clinical analysis of quadruple therapy containing Levofloxacin in the remedial treatment of 52 cases with Helicobacter pylori

目的探讨含左氧氟沙星四联方案在补救治疗幽门螺杆菌中的应用价值。方法选择消化性溃疡及慢性萎缩性胃炎患者102例,分为观察组和对照组,观察组患者应用雷贝拉唑、左氧氟沙星、阿莫西林及胶体果胶铋,对照组患者应用雷贝拉唑、阿莫西林、胶体果胶铋,治疗周期为14 d。结果治疗4周后,观察组中46例患者幽门螺杆菌阴性比例为88.5%,对照组中36例患者幽门螺杆菌阴性比例为72.0%,观察组患者幽门螺杆菌转阴率明显高于对照组(χ2=4.382 0,P=0.036 3)。两组患者不良反应发生率间差异无统计学意义(χ2=0.572 5,P=0.449 3)。结论含左氧氟沙星四联方案在补救治疗幽门螺杆菌中具有良好的效果。

Objective To investigate the value of quadruple therapy containing Levofloxacin in the remedial treatment of Helicobacter pylori. Methods 102 patients with peptic ulcer and patients with chronic atrophic gastritis were divided into two groups, the observation group was treated with Rabeprazole, Levofloxacin, Amoxicillin and Colloidal Bismuth Pectin. Control group was treated with Rabeprazole, Amoxicillin and Colloidal Bismuth Pectin, the treatment cycle was lg d. Re- suits After treatment for 4 weeks, 46 cases of patients with Helicobacter pylori-negative in the observation group, the ratio was 88.5%, 36 cases of patients with Helicobacter pylori-negative control group, the proportion was 72.0%, the pyloric screw bacilli negative conversion rate of the observation group was significantly higher （χ2 = 4.382 0, P = 0.036 3）. There was no significant difference between the adverse reaction rate of two groups （χ2 = 0.572 5, P = 0.449 3）. Conclusion The quadruple therapy containing Levofloxacin has a good effect in the remedial treatment of Helicobacter pylori.