孟鲁司特佐治急性荨麻疹临床疗效的观察分析

Clinical effect observation and analysis of montelukast in adjuvant treatment of acute urticaria

目的观察孟鲁司特佐治急性荨麻疹的疗效,为临床工作提供参考。方法选取急性荨麻疹患儿100例,随机分为对照组和观察组各50例。对照组患儿给予口服维生素C(Vit C)、地氯雷他定。观察组患儿在此基础上给予增加口服孟鲁司特。急性荨麻疹患儿连续口服1周,统计并比较观察组和对照组患儿临床疗效和复发率的差异。结果经过1周治疗后,对照组总有效率为84.0%,观察组总有效率为94.0%,两组比较,观察组明显高于对照组,差异有统计学意义(P<0.01)。停药后复发率对照组为18.0%,观察组为8.0%,两组差异有统计学意义(P<0.05)。结论采用联合孟鲁司特佐治急性荨麻疹可以取得较满意的临床疗效,且可降低复发率。

Objective To observe the curative effect of montelukast in the adjuvant treatment of acute urticaria, and to provide clinical reference. Methods One hundred children suffered from acute urticaria were selected, and were randomly divided into control group and observation group 50 children in each. The control group was given Vitamin C and desloratadine through the mouth, while the observation group was given Vitamin C, desloratadine and montelukast. The children suf- fered from acute urticaria took orally for a week, then calculated and compared the difference of curative effect and recurrence rate in both groups. Results After the treatment for a week, the effective rate of the control group was 84.0%, and which in the observation group was 94.0%. Compared the two groups, the observation group was better than the control group, and the difference had statistical significance （P 〈 0.01）. The recurrence rate after drug withdrawal of the control group was 18.0%, while the observation was 8.0%, the difference had statistical significance （P 〈 0.05）. Conclusion Using montetukast as the adjuvant treatment of acute urticaria can get satisfied results and lower the recurrence rate.