高州市2011年疑似预防接种异常反应监测分析

Analysis of AEFI monitoring in 2011 of Gaozhou City

目的分析2011年高州市AEFI监测系统报告的疑似预防接种异常反应,评价预防性生物制品的安全性,探寻目前AEFI监测的高效性。方法对《中国免疫规划监测信息管理系统》监测报告信息进行评估和整理,并作描述性分析。结果 2011年报告接种23类预防性生物制品692 640剂次,其中发现9种制品9例AEFI,AEFI发生率为1.299/10万。各类疫苗的AEFI发生率差异无统计学意义。AEFI多于24 h内发生在≤1岁婴儿中,发生类型以不良反应为主,其次为偶合症。临床表现常见发热、皮疹。结论选用免疫效果好且安全性高的疫苗,加强医务人员的培训,加强接种对象及监护人的宣传教育,可减少AEFI的发生。应完善城乡二级网络,提高AEFI报告的灵敏度,做到及时发现报告并控制。

Objective To analyze the adverse events following immunization which were reported by AEFI monitoring system in Gaozhou City in 2011, evaluate the safety of the prophylactic biological products and explore the efficiency of AEFI monitoring. Methods The information on China immunization monitoring information management system were evaluated, collated and analyzed. Results 692 640 inoculations involving 23 types of preventive biological products were reported in 2011. AEFI occurred in 9 patients involving 9 products. The incidence of AEFI was 1.299/100, 000. AEFI incidence among the types of vaccines had no significant difference. AEFI often occurred in children younger than 1 year in 24 hours. Ad- verse reaction was the main type of AEFI, which followed by coupling. The clinical manifestations included fever and rash. Conclusion Selecting vaccine with good effects and high safety, enhancing the training of medical staff, strengthening the publicity and education for Vaccinated subjects and their guardians can reduce the occurrence of AEFI. It should improve the network between urban and rural, and increase the sensitivity of AEFI reports. AEFE should be reported immediately and controlled when it was discovered.