导管相关性尿路感染队列研究

A cohort study of catheter-associated urinary tract infection

目的调查导管相关性尿路感染(catheter-associated urinary tract infections,CAUTI)发病及危险因素。方法队列随访湖北省某三甲医院入住ICU且接受尿路插管的424名患者,调查其CAUTI危险因素暴露及尿路感染发病情况,应用Logistic回归分析CAUTI的危险因素。结果该医院ICU患者CAUTI发病率为20.52%,发病密度为33.05/1 000尿路插管日。CAUTI发病的危险因素有:尿路插管时间≥7 d、前列腺肥大、抗菌药物使用≥5 d。最常见的病原体为白色念珠菌、肠球菌和大肠杆菌。结论该院ICU内CAUTI发病水平较高,应针对感染的危险因素加强预防与控制措施。

Objective To investigate the prevalence and risk factors of catheter-associated urinary tract infections（CAUTI） in Hubei Province.Methods The cohort study was conducted in an ICU in a tertiary care hospital in Hubei Province.All subjects were selected from patients after urinary catheterization in the ICU.A multivariable Logistic regression model was performed to identify the independent risk factors for CAUTI.Results Among patients,the incidence rate of CAUTI was 20.52%,and the density of infection was 33.05 / 1 000 catheter-days.By the multivariable Logistic regression analysis,the CAUTI risk factors included the duration of catheterization（≥7 d）,benign prostatic hypertrophy（BPH） and the duration of antimicrobial treatment（≥5 d）.Conclusions The incidence rate of CAUTI among patients was higher than those of the developed countries,and the prevention and control of CAUTI should be strengthened to improve the situation.