摘要
目的通过检测脆性组氨酸三联体(FHIT)蛋白在皮肤鳞状细胞癌(SCC)、鲍温病(BD)、日光角化病(SK)及正常对照皮肤组织中的表达情况,探讨FHIT与SCC发生及演进的关系。方法采用免疫组织化学PV-6000法,检测50例SCC、20例BD、15例SK及10例正常对照皮肤组织中FHIT的表达水平。结果对照组和BD组、SCC组,SK组和SCC组,高分化组和中低分化组,无淋巴结转移组和有淋巴结转移组FHIT蛋白的表达比较,差异均有显著性(χ2=3.972～10.500,P均<0.05)。结论 FHIT蛋白的异常表达与SCC的发生、演进密切相关。
Objective To investigate the expression of fragile histidine triad （FHIT） in squamous cell carcinoma （SCC）, Bowen＇s disease （BD）, solar keratosis （SK） and normal skin tissue, and explore the relationship between FHIT and the occur rence and development of SCC. Methods The expression of FHIT protein in SCC （50 cases）, BD （20）, SK （15） and normal skin （10） was detected by immunohistochemical PV-6000 method. Results A comparison between normal tissue and BD, or SCC, SK, SCC, well-, moderately-, poorly-differentiated group, with or without-lymph node metastasis was significant in terms of FHIT expression （χ^2 =3. 972-10. 500,P〈0.05）. Conclusion The abnormal expression of FHIT protein is closely related to the occurrence and progression of SCC.
出处
《齐鲁医学杂志》
2012年第4期286-288,共3页
Medical Journal of Qilu
