摘要
目的探讨幼年特发性关节炎(JIA)病儿外周血细胞毒性T淋巴细胞相关抗原-4(CTLA-4)的表达及其临床意义。方法应用流式细胞仪分别检测36例JIA病儿和39例健康儿童(对照组)外周血T淋巴细胞上CTLA-4表达及淋巴细胞亚群变化。结果 JIA病儿CD4+T和CD8+T细胞上CTLA-4的表达较对照组均显著增高,差异有显著性(t=27.10、26.28,P<0.01);CD3+CD4+T细胞较对照组显著增加,CD3+CD8+T细胞较对照组显著降低,差异有显著性(t=8.01、4.47,P<0.01)。结论 JIA病儿外周血T淋巴细胞CTLA-4的表达异常可能是JIA发病的重要机制之一。
Objective To investigate the expression of costimulatory molecule CTLA-4 in peripheral blood T lympho- cytes and its clinical significance in juvenile idiopathic arthritis （JIA）. Methods By using flow cytometry, the changes of expres- sion and lymphocyte subsets in 36 children with JIA, and 39 healthy controls were detected. Results In JIA children, the ex- pression of CTLA-4 in CD4^＋T and CD8^＋ T cells was higher than that in the control, the difference between them was significant 0=27.10,26.28;P〈0.01）; that of CD3^＋ CD4^＋ T cells was higher than that of the control group （t= 8.01,P〈0.01）, and CD3^＋ CD8^＋ T was lower （t=4.47,P〈0.01）. Conclusion The abnormal expression of CTLA-4 in T lymphocytes may be one of the causes contributing to JIA.
出处
《齐鲁医学杂志》
2012年第4期346-347,351,共3页
Medical Journal of Qilu
