柳氮磺吡啶、氢化可的松、刺五加注射液联合灌肠治疗溃疡性结肠炎的临床研究

THE CLINICAL STUDY OF SULFASALAZINE,HYDROCORTISONE COMBINED WITH ACANTHOPANAX INJECTION IN TREATMENT OF ULCERATIVE COLITIS

目的观察柳氮磺吡啶、氢化可的松联合刺五加注射液灌肠治疗溃疡性结肠炎的临床疗效。方法将2008年6月—2011年6月收治的溃疡性结肠炎患者64例随机分为2组,观察组和对照组各32例,观察组采用柳氮磺吡啶、氢化可的松、刺五加注射液联合灌肠治疗,对照组仅采用柳氮磺吡啶、氢化可的松灌肠治疗,比较2组的临床症状指标、肠镜指标疗效。结果观察组的临床症状和肠镜指标显效率均明显高于对照组(P<0.05),而2组临床症状和肠镜指标总有效率比较,差异无统计学意义(P>0.05)。结论柳氮磺吡啶、氢化可的松、刺五加注射液联合灌肠治疗溃疡性结肠炎,能够明显提高疗效,值得临床推广应用。

Objective To observe the effect of sulfasalazine, hydrocortisone combined with acanthopanax injection in treating ulcerative colitis. Methods A total of 64 cases of ulcerative colitis patients from June 2008 to June 2011 ,were divided into control group and observation group, patients in observation group were treated with the sulfasalazine, hydrocortisone and acanthopanax injection enema, and sulfasalazine, and hydrocortisone enema for patients in control group. The clinical effect and colonoscopic indicators between two groups were compared. Results The excellent rates of clinical symptoms and colonoscopic indicators in observation group were significantly higher than those in control group （P 〈 0.05 ）. But there were no significant differences in total effective rate of clinical symptoms indicators and colonoscopic indicators between two groups （ P 〉 0.05 ）. Conclusion Sulfasalazine, hydrocortisone combined with acanthopanax injection in treatment of ulcerative colitis can enhance clinical effect, which can be applied clinically.