咽喉反流88例患者的临床研究

CLINICAL STUDY OF 88 CASES OF LARYNGOPHARYNGEAL REFLUX

目的 探讨质子泵抑制剂（proton pump inhibitor,PPI）联合胃动力药治疗咽喉反流（laryngopharyngeal reflux,LPR）患者的临床疗效.方法 本文按照随机数字表法将LPR患者88例随机分为观察组和对照组,其中观察组采用奥美拉唑联合多潘立酮治疗,对照组单独给予奥美拉唑治疗,比较2组患者的临床疗效及不良反应.结果 观察组中显效31例,有效9例,总有效率达90.90%;对照组中显效22例,有效11例,总有效率为75.00%;观察组的显效率和总有效率均明显高于对照组,差异有统计学意义（χ2=3.90、3.96,P＜0.05）.观察组的主要临床症状平均消失时间均明显较对照组缩短,差异有统计学意义（t=3.75、3.32,P＜0.05）.2组患者纤维喉镜检查比较差异有统计学意义（χ2=6.30,P＜0.05）.结论 奥美拉唑联合多潘立酮治疗LPR比单用奥美拉唑有更好的临床疗效,不良反应小,值得临床推广.

Objective To investigate the clinical effect of proton pump inhibitor combined with motility drug in treatment of laryngopharyngeal refluxl Methods In accordance with the random number table,88 patients were randomly divided into observation group and control group. The observation group were treated with omeprazole and domperidone, control group given omeprazole treatment alone, the clinical efficacy and adverse reactions of the two groups were compared. Results In the observation group ,31 cases were markedly effective, 9 cases were effective, total effective rate was 90.90%. In the control group ,22 cases were markedly effective, 11 cases were effective ,total effective rate was 75.00%. The markedly effective rate and the total effective rate of the observation group were significantly higher than the control group, and the difference was statistically significant （ X2 = 3.90,3.96, P 〈 0.05 ）. The average clinical symptoms disappeared time in the observation group was shorter than the control group, and the difference was statistically significant （ t = 3.75,3.32, P 〈 0.05 ）. The fibrolaryngoscope result between the two groups after treatments had significant difference （ X2 = 6.30, P 〈 0.05 ）. Conclusion Omeprazole combined with domperidone had better clinical effect in treatment of by comparing with the group using omeprazole alone. laryngopharyngeal refluxby comparing with the group using omeprazole alone.