氨基末端-B型脑钠肽前体对急性呼吸困难鉴别诊断的临床观察

Clinical observation of N - terminal pro - brain natriuretic peptide in the differential diagnosis of acute dyspnea

目的观察氨基末端-B型脑钠肽前体（NT—proBNP）在急性呼吸困难鉴别诊断中的临床意义。方法用电化学发光免疫法（ECLIA）测定186例急性呼吸困难患者血浆NT—proBNP浓度，包括心源性呼吸困难（A组）和肺源性呼吸困难（B组），观察两组血浆NT—proBNP浓度。结果血浆NT—proBNP浓度在A组明显高于B组，差异有统计学意义（P〈0．01）；在A组，血浆NT—proBNP浓度与左室射血分数（LVEF）呈负相关（P〈0．01）。结论NT—proBNP在急性呼吸困难鉴别诊断中有重要的临床价值。

Objective To observe the clinical value of N - terminal pro - brain natriuretic peptide（NT -proBNP）in the differential diagnosis of acute dyspnea. Methods We determined plasma NT - proBNP concentration by electricity chemiluminescence immunoassay （ECLIA） in 186 patients with acute dyspnea, who were divided into two groups： cardiac dyspnea （group A）and pulmonary dyspnea （group B）. The plasma NT- proBNP concentration were compared in group A and group B. Results The plasma NT - proBNP concentration was significantly higher in group A than in group B （P 〈0.01 ）;in group A, the plasma NT- proBNP concentration was negatively correlated with left ventricular ejection fraction （P 〈 0. 01 ）. Conclusion The plasma NT - proBNP was helpful in the differential diagnosis of acute dyspnea.