丙氨酰－谷氨酰胺对AECOPD患者治疗作用的研究

Role of N （2） - L - alanyl - L - glutamine in the patients with AECOPD

目的探讨丙氨酰-谷氨酰胺（Ala—Gin）对慢性阻塞性肺疾病急性加重期（AECOPD）患者营养和免疫水平的影响。方法AECOPD患者50例，随机分为两组：试验组（A组）在复方氨基酸（8．5％乐凡命，18AA—II，华瑞制药）500mL中加入丙氨酰-谷氨酰胺0．50g/g缓慢静脉滴注，时间不少于6h。对照组（B组）仅应用复方氨基酸（8．5％乐凡命，18AA—II，华瑞制药）500mL静脉滴注。两组基础治疗相同。于第1、3、5、7天晨抽取患者静脉血，采用免疫比浊法测定血清前白蛋白和免疫球蛋白，全自动血液分析仪测定淋巴细胞计数。结果与B组相比较，A组第7天血清前白蛋白、免疫球蛋白、淋巴细胞计数均升高，差异有统计学意义（P〈0．05）。结论AECOPD患者营养支持中补充丙氨酰-谷氨酰胺能改善营养状况，提高免疫力。

Objective To evaluate the effect of N（2） - L - alanyl - L - glutamine（ Ala - Gin） on the pre - albumin and immune globulin in acute exacerbation of chronic obstructive pulmonary disease （AECOPD）patients who accepted nutritional support treatment. Methods Fifty AECOPD patients were randomly divided into two groups, experimental group： Ala - Gin 0.50 g/（ kg·d） was added into the compound amino acid. Intravenous injection time was not less than 6 hours. In the control group, nitrogen was provided by the compound amino acid （8. 5% of Le Fan Ming, Huarui pharmaceuticals companies）. Both groups were given the same basic treatment. The time lasted for 7 d. Prealbumin, immunoglobulin and lymphocyte counts were detected. Results Compared with the control group, the number of pre - albumin, immunoglobulin IgA and IgM, lymphocyte counts were higher at 7 d. The difference was statistically significant （P 〈 0.05）. Conclusion The supplement of alanyl - glutamine （AlaGin） to the AECOPD patients who received parenteral and enteral nutrition can not only improve the nutritional status but also significantly enhance the immunity.