1-(5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基-1H-吡唑-3-基)-3-(吡啶-3-基甲基)脲的合成

Synthesis of 1-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)-3-(pyridine-3-ylmethyl)urea

以5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基-1H-吡唑-3-甲酸与二氯亚砜为起始原料,经酰氯化反应、酰胺反应、霍夫曼重排以及水解反应生成中间体5-(4-氯苯基)-1-(2,4-二氯苯基)-3-氨基-4-甲基-1H-吡唑,再经过与氯甲酸苯酯反应、胺酯交换反应得到标题化合物,其结构经1HNMR、MS谱确证,总收率26.9%。

5-（4-chlorophenyl-1-（2,4-dichlorophenyl）-4-methyl-1H-pyrazol-3-carboxylic acid was acted as starting material,intermediate 5-（4-chlorophenyl-1-（2,4-dichlorophenyl）-4-methyl-1H-pyrazol-3-amino-4-methyl-1H-pyrazole was obtained via the reaction of acyl chloridation,amidation,Hoffman rearrangement and hydrolysis.Then the intermediate was reacted with phenyl chloroformate and at last the target compound was synthesized by the amine-ester exchange reaction.The structure was confirmed by MS and 1HNMR.The total yield was 26.9%.