湖州市弁南乡高中以下学生乙型肝炎病毒感染者3年随访分析

Analysis of Three-Years Investigations of Hepatitis B Patients among Students Prior to Junior Middle School in Munan.

［目的］了解农村高中以下在校学生急慢性乙肝感染的特点、疗效和转归。［方法］在问卷和乙肝病毒（ＨＢＶ）感染调查基础上，对ＨＢｓＡｇ阳性者经乙型肝炎五项血清标志物（ＨＢＶＭ）检测，对已确诊的４２例乙肝患儿随访３年后集中检测ＨＢＶＭ和肝功能，同时对３１例做ＨＢＶ－ＤＮＡＰＣＲ对照检查。［结果］高中以下学生ＨＢＶ自然感染率为５．１７％，其中呈急慢性感染占４５．２％，且以男生为绝大多数（９０． ５％）。母婴间垂直传播，明显的家族聚集和使用消毒不严的注射器是农村儿童感染ＨＢＶ的主要原因。［结论］儿童感染ＨＢＶ，大多呈无症状和慢性带毒特点，其最终疗效取决于ＨＢＶ复制水平、病毒变异和机体的免疫状态。

Objective] To understand the characteristics treatment effect and recovery of current hepatitis B students in the rural area. [Mothods] Based upon the comprehensive exams and the data of five serum indices (HBVM) among the hepatitis B virus(HBV) positive patients, 42 students patients were screened and followed with investigation of their HBVM indices and liver functionality while comparing with references. [Results] 51. 7 % of students prior to junior middle school were potentially infected. Among those,45. 2 % were infected either acutely or chronically. Moreover, the vastmajorities were boys(90. 5 % ). The main reasons of infections among the rural students bade such characteristics as vertical infection between mother and infant,family history and the usage of injector unsterilized. [Conclusion] Children infected with HBV usually had common features included no symptoms and chronically carrying virus. The recovery basically depends upon the level of HBV duplication virus variation and resistibility of the body.