两种杂二齿螯合物的合成

Synthesis of Two Heterobidentate Ligands

研究两种具有光学活性的杂二齿螯合物（1S,2S）-2-{甲基[（R）-3甲基-2-丁基]氨基）-1-苯基-1-丙醇和（1R,2R）-2-氨基-1-苯基-1-丙醇的合成方法。分别以麻黄碱和苯甲醛为原料通过成环、还原等方法得到光学活性单一的目标化合物,其结构通过~1H NMR确认。设计的合成路线有收率高、反应条件相对温和、生成物光学活性单一等特点。

Synthetic Methods of two heterobidentate ligands,（1S,2S）-2-{methyl[（R）- 3methybuan-2-yl]amino}-l-phenylpropan-l-ol and（1R,2R）-2-amino-l-phenylpropan-l-ol were investigated.The target optically active-single compounds were synthesized by cyclization,reduction methods with ephedrine and benzaldehyde as raw materials,respectively,and the structures of compounds were confirmed by ~1H NMR.The synthetic routes has characteristics,such as high recovery,relative mild reaction conditions and single-optical activity.