病毒性心肌炎患者细胞免疫功能检测的临床价值

Clinical value of detection of cellular immune function of patients with viral myocarditis

目的探讨病毒性心肌炎患者细胞免疫功能检测的临床价值。方法选取医院收治的病毒性心肌炎患者112例作为病毒性心肌炎组,另选取同期健康体检112人作为健康组,对两组免疫功能进行比较;对病毒性心肌炎患者采用中西医结合的方法进行治疗,比较患者治疗前后免疫功能变化。结果病毒性心肌炎组CD3+为(45.66±6.67)%;CD4+为(35.42±6.17)%;CD8+为(23.56±5.14)%;CD4+/CD8+比值为1.43±0.23较健康组显著降低;病毒性心肌炎组经治疗后,CD3+为(61.33±6.69)%;CD4+为(47.16±6.38)%;CD8+为(28.71±5.67)%;CD4+/CD8+比值为1.79±0.31,较治疗前T淋巴细胞亚群免疫指标显著上升;病毒性心肌炎组经治疗后,TNF和sIL-2R水平均降低,差异均有统计学意义(P<0.05)。结论病毒性心肌炎患者多存在不同程度的细胞免疫功能低下,临床医师应提高病毒性心肌炎患者的免疫功能。

OBJECTIVE To explore the clinical value of detection of cellular immune function in the patients with viral myocarditis.METHODS A total of 112 cases with viral myocarditis were selected as the viral myocarditis group,112 healthy people as the healthy group,the cellular immune function was compared between two groups;the viral myocarditis patients were given the treatment of integrated Chinese traditional and Western medicine,the change of cellular immune function was compared before and after the treatment.RESULTS Compared with healthy group,T-lymphocyte subset indexes had decreased significantly in the vital myocarditis group：as CD3＋ was（45.66±6.67）%;CD4＋（35.42±6.17）%,CD8＋（23.56±5.14）%,CD4＋/CD8＋（1.43±0.23）;after the treatment,T-lymphocyte subset indexes increased significantly：as CD3＋ was（61.33±6.69）%,CD4＋（47.16±6.38）%,CD8＋（28.71±5.67）%,CD4＋/CD8＋（1.79±0.31）;after the treatment,the levels of both TNF and sIL-2R were decreased in the increased vital myocarditis group,with statistical significance.CONCLUSION The cellular immune function is low in varying degrees in the patients with viral myocarditis so that the clinician should focus on improving the immune function of the patients with viral myocarditis.