哌拉西林/他唑巴坦在急性弥漫性腹膜炎围手术期的应用

Piperacillin/tazobactam for acute diffuse peritonitis during perioperative period

目的探讨急性弥漫性腹膜炎抗菌药物治疗方法。方法回顾性分析2011年2月-2011年7月医院普外科行手术治疗的急性弥漫性腹膜炎36例,术中常规行腹腔脓液细菌培养及药敏试验,围手术期应用哌拉西林/他唑巴坦及甲硝唑联合抗感染。结果所有患者皆临床治愈;住院时间5～25d,平均13.5d;88.9%的病原菌对哌拉西林/他唑巴坦敏感,所有病例无腹腔残余脓肿发生。结论哌拉西林/他唑巴坦在急性弥漫性腹膜炎经验性抗菌药物治疗中安全、有效。

OBJECTIVE To investigate the use of antibiotics for treatment of acute diffuse peritonitis.METHODS The data of 36 patients with acute diffuse peritonitis who underwent surgical operation from Feb 2011 to Jul 2011 were analyzed retrospectively.Germ culture for purulence derived from abdominal cavity and drug susceptibility testing was performed during the operation,and piperacillin/tazobactam（4：1）plus metronidazole were used for anti-infection therapy during perioperative period.RESULTS All the patients were cured;the duration of hospital stay ranged from 5 days to 25 days,with 13.5 days in average;88.89% of the pathogens were proved susceptible to piperacillin/tazobactam,there was no case with residual intraperitoneal abscess.CONCLUSION Piperacillin/tazobactam is effective and safe in experiential treatment of acute diffuse peritonitis during the perioperative period.