组合药物——现代药物研发的新趋势

Combinational Drug——An New Trend of the Development of Modern Drugs

人体是一个复杂的网络系统,疾病往往是多个因素综合作用的结果,其发病机制可理解为多途径、多靶点的网络变化,单一靶点的药物治疗模式已不能满足复杂疾病的治疗要求。系统生物学、网络药理学等网络科学的提出,为组合药物的研制和开发提供了强有力的理论和技术支撑。该文将组合药物作为关键问题,介绍了现代组合药物的缘起、概念及目前中、西药物的发展趋势,明确指出组合药物的产生是人体复杂生命系统以及多致病机制的客观要求,其融合了中、西药物的优势特征,是现代药物发展的新趋势,具有广阔的开发和应用前景。

Human body is considered as a complex network system,its pathogenesis is resulted from interactions of various factors,molecular network anomalies including multi-pathway and multi-target.So the treatment mode of drug with the only single target can not meet the demands of the complex diseases.It has given a powerful support to utilization of combinational drug with the emergence of network science such as system biology,network pharmacology.In this paper,taken as a key point,the origin,concept of combinational drug and trend of development in combination of Chinese and Western medicine have been reviewed in detail.It is also clarified in this paper that the generation of drug combination which integrates the advantage of characteristics of Chinese and Western medicine is the objective requirements of the complex human life system and the multiple pathogenic mechanisms,as well as the inevitable trend of modern drug development and show a broad development and application prospect.